主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (6): 414-419.doi: 10.3969/j.issn.1006-2157.2014.06.013

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Quality characteristics and correlation analysis of medicinal preparations from Zisu Fang

AN Qi1, TANG Xue-yang2, LU Guang-ying2, WEN Jing2, MEI Ying-ying2, ZUO Sheng2, ZHU Nai-liang2, WANG Chun-mei2, ZHOU Yong-qiang5, ZHANG Xiao-lei5 , WANG Yong-yan4, SHI Ren-bing2, 3   

  1. 1 School of Traditional Chinese Medicine,Capital University of Medical Sciences,Beijing 100069;
    2 Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese Medicine,School of Chinese Pharmacy,Beijing University of Chinese Medicine;
    3 Shanghai Green Valley Pharmaceutical Co.,Ltd.
    4 China Academy of Chinese Medical Sciences;5 Quality Control Technology and Engineering Center of Chinese Medicine,Beijing Municipal Commission of Education
  • Received:2014-02-10 Online:2014-06-30 Published:2014-06-30

Abstract: Objective To determine the best preparation forms of medicinal in Zisu Fang,and answer the question of how to develop high-quality medicinal. Methods The content of baicalin,salvianolic acid B,rosmarinic acid,tanshinone ⅡA,matrine,oxymatrin﹙effective index components in different medicinal preparation forms from Zisu Fang﹚were detected by using HPLC-PDA under acidic and alkaline systems.The quality of medicinal preparation from Zisu Fang were characterized based on the content,relative quantity,relative ratio of content,yield rate and antibacterial effect in vitro and in vivo,and the characterized results were given correlation analysis. Results The content of 6 kinds of effective index component﹙totally 53.43%﹚in enrichment from Zisu Fang increased significantly,which was 3.2 times higher than in ethanol extract and 3.6 times higher than in water extract,and the yield rate decreased by one-third of that of ethanol extract and water extract.The relative ratio of components was more reasonable,and medicinal system had higher antibacterial effect in vitro and in vivo.The enrichment was the best preparation form of medicinal in Zisu Fang. Conclusion It is an important way for develop high-quality medicinal to explore the fittest content and relative ratio of medicinal components based on the basic composition of medicinal system and yield rate.

Key words: Zisu Fang, medicinal system, quality characteristics, correlation analysis

CLC Number: 

  • R284.1