主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (7): 463-466.doi: 10.3969/j.issn.1006-2157.2014.07.006

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Influences of Xuezhikang Capsules on blood fat level and vascular endothelial function in CHD patients with different TCM constitutional types

TIAN Song, QI Ruo-ke, WU Xiao-xue, HE Qian, CHENG Yue-zhao   

  1. Shanxi University of Traditional Chinese Medicine, Shanxi 030024
  • Received:2014-03-19 Online:2014-07-30 Published:2014-07-30

Abstract: Objective To definite the lipid-lowering effect of Xuezhikang Capsules, and discuss the influence of TCM constitutional factors on the curative effect of Xuezhikang Capsules. Methods The patients with coronary heart disease (CHD) and 4 constitutional types (n=50) were randomly selected as treatment group, 50 patients with CHD were selected as control group, and other 50 health volunteers were selected as health group. The control group was treated with routine therapy, and treatment group was additionally given Xuezhikang Capsules for 12 w. The changes of levels of endothelin-1 (ET-1), nitric oxide (NO) and blood fat were observed before and after treatment. Results All lipid indexes had significant difference in blood stasis constitution group and phlegm dampness constitution group after treatment compared with those before treatment and those in control group after treatment (P<0.05). The level of LDL-C had significant difference in qi deficient constitution group after treatment compared with those before treatment and those in control group after treatment (P<0.05). The indexes of vascular endothelial function had significant difference in blood stasis constitution group and phlegm dampness constitution group after treatment compared with those before treatment and those in control group after treatment (P<0.05). The curative effects on angina pectoral and electrocardiogram were better in blood stasis constitution group and phlegm dampness constitution group than those in qi deficient constitution group and yang deficient constitution group (P<0.05). Conclusion The overall curative effect and improving effects of Xuezhikang Capsules on blood fat and vascular endothelial function are better in CHD patients with blood stasis constitution or phlegm dampness constitution than those in CHD patients with qi deficient constitution or yang deficient constitution.

Key words: Xuezhikang Capsules, constitution, coronary heart disease, blood fat, endothelial function

CLC Number: 

  • R259.414