主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (7): 481-485.doi: 10.3969/j.issn.1006-2157.2014.07.010

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Quality reviewing of Gaoben (Rhizoma Ligustici) based on drug system

ZUO Sheng1, SUN Ya-shu1, CHI Lei1, MEI Ying-ying1, AN Qi3, JIANG Yan-yan1,2, ZHANG Shuo-feng1, ZHOU Yong-qiang5, ZHANG Xiao-lei5, WANG Yong-yan4, SHI Ren-bing1,2   

  1. 1 Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese Medicine, School of Chinese Pharmacy, Beijing University of Chinese Medicine; Beijing 100029;
    2 Quality Control Technology and Engineering Center of Chinese Medicine, Beijing Municipal Commission of Education;
    3 School of Traditional Chinese Medicine, Capital University of Medical Sciences;
    4 China Academy of Chinese Medical Sciences;
    5 Shanghai Green Valley Pharmaceutical Co., Ltd.
  • Received:2014-03-26 Online:2014-07-30 Published:2014-07-30

Abstract: Objective To establish the quality representation of Gaoben (Rhizoma Ligustici) and correlation analysis method based on drug system, and provide a new mode for quality evaluation of Chinese medicinal. Methods HPLC method was used for simultaneous determination of 5 effective index components in 7 batches of Gaoben decocting pieces, including ferulic acid, senkyunolide A, senkyunolide H, senkyunolide I, and ligustilide, and then a correlation analysis was carried out;The quality representation based on the content relative ratio of key effective index components showed as follows: taking the content of senkyunolide I as reference, the quality representations of decocting pieces were determined based on the content relative ratio of effective index components, and using batch 4 (decocting pieces with identified therapeutic effect) as baseline for getting the difference between these relative ratio of effective index components, and its sum of absolute value represented as non-correlation coefficient. Results The quality representation based on the content of effective index components showed as follows: by the content of ferulic acid, the sorting was batch 7>batch 6>batch 4>batch 3>batch 1>batch 5>batch 2 and the maximum content difference was about 2.2 times; by the content of senkyunolide I, the sorting was batch 7>batch 4>batch 3>batch 6>batch 1>batch 5>batch 2 and the maximum content difference was about 4.9 times; by the total content of phthalides, the sorting was batch 7>batch 3>batch 6>batch 4>batch 1>batch 2>batch 5 and the maximum content difference was about 3.6 times. The total content of effective index components was higher in batch 7, batch 3, batch 4 and batch 6. The sorting of the correlation degree ( δ/correlation degree) was analyzed as batch 4 (0/100%)>batch 7 (1.21/79.8%)>batch 3 (1.36/77.3%)>batch 6 (1.83/69.5%)>batch 5 (2.18/63.7%)>batch 1 (2.28/62.0%)>batch 2 (9.14). The results indicated that the correlation degree was higher between the quality representations of batch 7 or batch 3 and that of batch 4. Conclusion The analysis on the correlation degree of quality representation is conducted based on the content of effective index components and content relative ratio and taking decocting pieces with identified therapeutic effects as baseline for evaluating the overall correlation of quality and the effectiveness of application.

Key words: Gaoben (Rhizoma Ligustici), quality evaluation, correlation analysis, ferulic acid, senkyunolide A, senkyunolide H, senkyunolide I, ligustilide

CLC Number: 

  • R284.1