主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (7): 490-494.doi: 10.3969/j.issn.1006-2157.2014.07.012

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Influences of antagonistic medicianl combination of Haizao (Sargassum) and Gancao (Radix Glycyrrhizae) in Haizao Yuhu Tang on functions of liver and kidney in rats

LIU Yun-xiang1, ZHONG Gan-sheng1, LIU Hai-yan1, LI Yi-wen2, OU Li-na1, LIU Ming1, ZHAO Tong1   

  1. 1 School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029;
    2 China Meitan General Hospital
  • Received:2014-02-24 Online:2014-07-30 Published:2014-07-30

Abstract: Objective To investigate the influences of antagonistic medicianl combination of Haizao (Sargassum) and Gancao (Radix Glycyrrhizae) in Haizao Yuhu Tang on functions of liver and kidney in rats. Method All Wistar rats were randomly divided into blank group, model group ,positive drug group, whole formula group, non-Haizao group, non-Gancao group and non-Haizao non-Gancao group, and except of normal group, other groups were orally given propylthiouracil for establishing goiter model. Taking Euthyrox 0.02 mg/kg as a positive control drug, and all groups were given corresponding medicinal 14 g/kg once a day for 28 d. The coefficients of liver and kidney and serum indexes related to liver and kidney functions were detected in rats of all groups. Results The coefficients of liver was significantly lower in model group and all Chinese medicinal groups than that in normal group and positive drug group (P<0.05). The levels of ALT, AST and ALP were significantly higher in model group than that in normal group, and trended to normal in positive drug group, non-Haizao group, non-Gancao group and non-Haizao non-Gancao group. Compared with normal group and model group, the level of albumin (ALB) increased in non-Haizao group and decreased in non-Haizao non-Gancao group (P<0.05). The value of globulin (GLB) was significantly lower in non-Gancao group than that in normal group and model group (P<0.05), and value of total protein (TP) was lower in model group, non-Gancao group and non-Haizao non-Gancao group than that in normal group (P<0.05). The level of blood urea nitrogen (BUN) was higher in model group, whole formula group, non-Haizao group and non-Haizao non-Gancao group than that in normal group (P<0.05). The level of uric acid (UA) was lower in non-Gancao group and non-Haizao non-Gancao group than that in model group (P<0.05). The level of serum creatinine (Scr) had no significant difference among all groups. Conclusion The antagonistic medicianl combination of Haizao and Gancao in Haizao Yuhu Tang has no significant effects on liver and kidney functions in rats.

Key words: Haizao (Sargassum), Gancao (Radix Glycyrrhizae), antagonistic medicianl combination, Haizao Yuhu Tang, functions of liver and kidney, rats

CLC Number: 

  • R285.5