主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (8): 538-542.doi: 10.3969/j.issn.1006-2157.2014.08.009

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Influence of Qishen Yiqi Gutta Pills on RAAS in rats with heart failure

CHEN Hui, LI Chun, SHI Tian-jiao, WANG Yong, CHANG Hong, HUO Kui-yuan, TANG Bing-hua, WANG Wei   

  1. School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029
  • Received:2014-03-15 Online:2014-08-30 Published:2014-08-30

Abstract: Objective To illustrate the improving effect of Qishen Yiqi Gutta Pills on hemodynamics in rats with heart failure after myocardial infarction (MI), and its influence on renin-angiotensin-aldosterone system (RAAS). Methods The rat model of heart failure after MI was established by using left coronary ligation, and then the rats were randomly divided into sham-operation group, model group, Qishen Yiqi Gutta Pills group and captopril group. The hemodynamic parameters were reviewed by using biological signal processing and analysis system, the content of Ren, AngII and ALD were detected by using radioimmunoassay, and level changes of AngII receptors (AT1 and AT2) and ACE were detected by using Western blot method. Results The results showed that the pathological changes of heart failure after MI occurred 28 d after ligation. Compared with sham-operation group, systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased significantly, and LVSP, +dp/dtmax and -dp/dtmax were significantly lower in model group. RAAS were activated accompanied by the increase of ACE and AT1 and decrease of AT2. SBP and DBP were improved in Qishen Yiqi Gutta Pills group and captopril group (P<0.05) and there was no statistical difference between these 2 groups. LVEDP and -dp /dtmax were up-regulated in Qishen Yiqi Gutta Pills group and captopril group, while in the aspect of inhibiting RAAS activation, Qishen Yiqi Gutta Pills down-regulated Ren and AngII, but had no effect on ALD. Qishen Yiqi Gutta Pills inhibited partly the expressions of AT1 and ACE, and up-regulated significantly AT2 expression. Captopril, as an inhibitor of ACE, had effects on ACE and AT1 mainly and had no effect on AT2. Conclusion Qishen Yiqi Gutta Pills can improve the hemodynamics in rats with heart failure after MI, and the mechanism may be related to that it can inhibit RAAS activation through reducing Ren and AngII, down-regulating ACE and AT1 and increasing AT2.

Key words: heart failure, Qishen Yiqi Gutta Pills, hemodynamics, RAAS, rats

CLC Number: 

  • R285.5