主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (8): 548-550.doi: 10.3969/j.issn.1006-2157.2014.08.011

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Influences of Huangqin Qingre Chubi Fang on content of IL-8, IL-10, TNF-α and visceral indexes in rats with adjuvant arthritis

JIANG Ying1, ZHANG Jing1, MENG Mei2, GE Ping1, YANG Jie2   

  1. 1 Anhui University of Traditional Chinese Medicine, Anhui 230038;
    2 First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
  • Received:2014-02-20 Online:2014-08-30 Published:2014-08-30

Abstract: Objective To study the influences of Huangqin Qingre Chubi Fang on content of interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and visceral indexes in rats with adjuvant arthritis (AA). Methods Male SD rats (n=60) were randomly divided into 6 groups (each n=10). The rat model of AA was established with Freund’s complete adjuvant in all groups except of normal group. After modeling for 12 d, different groups were orally given corresponding medicinal once a day for 12 d. The visceral indexes and content of IL-8, IL-10 and TNF-α were detected and compared in all groups. Results After treatment, the content of IL-8 and TNF-α increased significantly (P<0.01), and IL-10 content and visceral indexes decreased significantly (P<0.01) in model group compared with normal group. The content of IL-8 and TNF-α decreased significantly (P<0.05, P<0.01), and IL-10 content and visceral indexes increased significantly (P<0.05, P<0.01) in Huangqin Qingre Chubi Fang group compared with model group, which was more significant in high-dose group (P<0.01). The effective results had no significant difference between high-dose group and GTW Tablet group (P>0.05). Conclusion Huangqin Qingre Chubi Fang can reduce the content of IL-8 and TNF-α and raise visceral indexes and the content of IL-10, and plays a role of anti-inflammation and detumescence in rats with AA.

Key words: Huangqin Qingre Chubi Fang, visceral indexes, interleukin-8, interleukin-10, tumor necrosis factor-α, adjuvant arthritis, rats

CLC Number: 

  • R285.5