主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (8): 559-574.doi: 10.3969/j.issn.1006-2157.2014.08.014

Previous Articles     Next Articles

Treatment of hemoglobin H disease with Yisui Shengxue Granules in 35 cases

CHU Na-li1, ZHANG Xin-hua2, FANG Su-ping1, WANG Wen-juan3, CHENG Yan-ling1, WU Zhi-kui1   

  1. 1 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053;
    2 Chinese PLA 303 Hospital;
    3 Capital University of Medical Sciences
  • Received:2014-03-15 Online:2014-08-30 Published:2014-08-30

Abstract: Objective To investigate the curative effect of Yisui Shengxue Granules on hemoglobin H disease (HbH disease). Methods By applying self-control study, 35 patients with HbH disease (25 with non-defection HbH disease and 10 with defection HbH disease) were given Yisui Shengxue Granules for 3 m. The changes of blood parameters and quantitative scores of TCM syndromes were dynamically detected before and after treatment. The blood parameters included concentration of hemoglobin (Hb), count of RBC, count of reticulocyte (Ret) and content of HbH, and 6 syndromes of liver-kidney yin deficiency syndrome and essence-blood deficiency syndrome were selected including sallow complexion, dizziness and dizzy vision, torpid intake and poor appetite, tidal fever and night sweating, heat in palms and soles, and pale nails. Results From the first month to the third month of treatment, the levels of Hb, RBC and Ret increased significantly (P<0.01) in 35 patients with HbH disease. The levels of Hb and Ret increased significantly (P<0.01) in 25 patients with non-defection HbH disease, and level of Hb increased significantly (P<0.01) in 10 patients with defection HbH disease. From the first month to the third month of treatment, the quantitative scores of sallow complexion, dizziness and dizzy vision, heat in palms and soles, and pale nails decreased (P<0.01) in 35 patients with HbH disease. The quantitative scores of sallow complexion, heat in palms and soles, and pale nails decreased (P<0.01 or P<0.05) in 25 patients with non-defection HbH disease. The quantitative scores of sallow complexion, dizziness and dizzy vision, and tidal fever and night sweating decreased (P<0.01 or P<0.05) in 10 patients with defection HbH disease. After treatment for 3 m, the total effective rate was 62.7% in 35 patients with HbH disease, 60% in patients with defection HbH disease and 64% in patients with non-defection HbH disease. The comparison in effective rate between patients with 2 gene types had no statistical difference. Conclusion Yisui Shengxue Granules, a representative formula for tonifying kidney and marrow, has significant efficacy on HbH disease, which can improve the levels of Hb, RBC and Ret, and relieve TCM symptoms in the patients with HbH disease. The increase of blood parameters is consistent with the relief of TCM syndromes.

Key words: hemoglobin H disease, TCM syndromes, Yisui Shengxue Granules, blood parameters

CLC Number: 

  • R255.7