主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (9): 620-624.doi: 10.3969/j.issn.1006-2157.2014.09.011

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Solubilizing effect of glycyrrhizic acid on baicalin

LU Bing, YANG Xuan, WANG Bao-hua, SHI Xin-yuan, WANG Yan, LI Jie, SHAO Lu, YANG Bei-bei, LI Ping   

  1. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102
  • Received:2014-05-04 Online:2014-09-30 Published:2014-09-30

Abstract: Objective To discuss the mechanism of solubilizing effect of glycyrrhizic acid on baicalin through detecting surface tension and index component of combined decoction of Huangqin (Radix Scutellariae) and Gancao (Radix Glycyrrhizae) in different percentages. Methods The surface tension of the combined decoction in different percentages was detected by using Wihelmy plate method, content of baicalin and glycyrrhizic acid in different proportions was detected by using high performance liquid chromatography (HPLC), and retation graph was completed. Results When the ratio of Huangqin to Gancao was 3:2, the extraction rate of baicalin was the highest, and critical micelle concentration of glycyrrhizic acid was 0.22 g/L. When concentration of glycyrrhizic acid was lower than 0.22 g/L, dissolution rate of baicalin increased gradually as concentration of glycyrrhizic acid increased, ang when concentration of glycyrrhizic acid reached 0.22 g/L, dissolution rate of baicalin did not increase. Conclusion Glycyrrhizic acid has some solubilizing effect on baicalin, and when its critical micelle concentration reaches 0.22 g/L, its solubilizing effect is the higherst.

Key words: glycyrrhizic acid, baicalin, high performance liquid chromatography, surface tension

CLC Number: 

  • R283