主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2014, Vol. 37 ›› Issue (9): 625-628.doi: 10.3969/j.issn.1006-2157.2014.09.012

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Synthesis of baicalin-zinc complex and its inhibitory effect on human cervical carcinoma HeLa cells

YUAN Rui-juan1, WANG Bei-bei1, ZHAO Shuang1, SHEN Meng1, XU Yi-wen1, CHEN Xin2, TAN Peng1, TAO Ou1, LIU Yong-gang1   

  1. 1 School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102;
    2 School of Pharmaceutics Sciences, Peking University
  • Received:2014-03-11 Online:2014-09-30 Published:2014-09-30

Abstract: Objective To synthesize baicalin-zinc complex, and study its inhibitory effect on human cervical carcinoma HeLa cells. Methods Baicalin-zinc complex was synthesized by reaction between baicalin and zinc acetate, and then the complex was characterized by using ultraviolet-visible absorption spectrum, infrared spectrometry and mass-spectrography. The inhibitory effects of baicalin and baicalin-zinc complex on the proliferation of HeLa cells in vitro were detected by using CCK-8 method. Results Zinc ion (1 molecule) might combine with carboxyl of glucuronic acid (2 molecule) in baicalin to generate baicalin-zinc complex (1:2). The harf inhibitory concentration (IC50) of baicalin-zinc complex and that of baicalin on HeLa cells were, respectively, 12.03 mg/L and 8.69 mg/L. Conclusion Baicalin and baicalin-zinc complex both have anti-tumor activities in vitro, but when baicalin combines zinc to generate complex, the anti-cervical carcinoma activity will decrease.

Key words: baicalin, baicalin-zinc complex, HeLa cells

CLC Number: 

  • R284.3