主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (1): 14-17.doi: 10.3969/j.issn.1006-2157.2015.01.003

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Correlation between tumor inflammatory microenvironment and “cancerous toxin” pathogenesis

SHEN Zheng-jie1, CHENG Hai-bo1,2,3, SHEN Wei-xing1,2,3, WU Mian-hua1,2#   

  1. 1 Nanjing University of Chinese Medicine, Jiangsu 210023;
    2 Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor;
    3 Translational Medicine Center of Nanjing University of Chinese Medicine, Provincial Lab of Anticarcinoma Proved Recipe Research and Engineering Industrialization, Key Laboratory of Famous Doctor's Proved Recipe Evaluation and Transformation of State Administration of Traditional Chinese Medicine
  • Received:2014-10-25 Online:2015-01-30 Published:2015-01-30

Abstract: The tumor inflammatory microenvironment is a key component of tumor microenvironment. The transformation of controlled inflammation into uncontrolled inflammation occurring frequently in the process of carcinogenesis, eventually Results in the suitable microenvironment for promoting the proliferation, invasion, metastasis, angiogenesis and immune escape of tumor cells. Prefessor Zhou Zhong-ying, awarded “National Chinese Medical Science Master”, put forward the theory of cancerous toxin pathogenesis based on his long-term clinical experience, in which “cancerous toxin ”is the key factor in carcinogenesis and cancer growth. TCM pathological factors referred as cancerous toxin, phlegm turbidity, blood stasis, damp turbidity and toxic heat, lead to tumors by intermingling, transformation and interaction as cause-and-effect. The formation and pathogenesis of cancerous toxin are similar to the process of inflammation transformation into tumor in tumor inflammatory microenvironment. Cancerous toxin intermingled with the other pathological factors mentioned above have close correlation with, we believe, tumor cells interacting with immune cells and cytokines in tumor inflammatory microenvironment. Under the totally different viewpoints of Chinese and western medicine, the biological bases of theory of cancerous toxin pathogenesis on tumor formation and growth will be expected to elucidate, so as to provide a scientific basis for the theory applied to tumor.

Key words: cancer, inflammatory microenvironment, cancerous toxin pathogenesis, Chinese medicine pathogenesis

CLC Number: 

  • R273