主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (1): 68-72.doi: 10.3969/j.issn.1006-2157.2015.01.015

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Clinical observation of replenishing qi and nourishing yin formula reversing multidrug resistance of patients with refractory acute leukemia

YAN Li-xiang1, SHI Zhe-xin2#, JINAG Jing1, GUO Jiang-shui2, LIU Fu-chun1   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 300193;
    2 First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine
  • Received:2014-09-16 Online:2015-01-30 Published:2015-01-30

Abstract: Objective To observe the effect of replenishing qi and nourishing yin formula on reversing the multidrug resistance and the bone marrow cell cycle of patients with refractory acute leukemia(RAL). Methods Altogether 60 RAL patients were randomly divided into control group and treatment group (n=30 each). Control group was treated with conventional chemotherapy only, and treatment group was treated with conventional chemotherapy combined with replenishing qi and nourishing yin formula for 30 d. Peripheral hemogram, the bone marrow remission rate, the bone marrow cell cycle rate, TCM syndrome score and side effects were calculated before and after the treatment in both groups. Results After treatment, proportion of primitive bone marrow cells (original cells and juvenile cells) and white blood cell count decreased significantly compared with before treatment in both groups (P<0.05), and those of the treatment group decreased dramatically compared with control group (P<0.05). Bone marrow remission rate in treatment group with 60.00% (18/30) increased significantly compared with control group with 30.00% (9/30) (P<0.05). After treatment, the ratio of bone marrow cells in G0 /G1 phase was lower and the ratio of cells in S phase and G2/M phase was higher than control group (P<0.05). TCM syndrome score in treatment group decreased compared with treatment group (P<0.05). During the whole period treatment, the side-effects of myelosuppression, alopecia and gastrointestinal reactions appeared frequently, and the incidence in treatment group was lower than those in control group. Conclusion Replenishing qi and nourishing yin formula combined with conventional chemotherapy acquired better effectiveness with fewer side-effects, attributed to the inducing of leukemia cell into the cell cycle and increasing the chemosensitivity.

Key words: refractory acute leukemia, multidrug resistance, replenishing qi and nourishing yin formula, chemotherapy, bone marrow cell cycle

CLC Number: 

  • R255.7