主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (3): 186-189.doi: 10.3969/j.issn.1006-2157.2015.03.009

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Anti-inflammatory effect of Mongolian medicine compound Sendeng- 4 on adjuvant arthritis in rats*

BAI Pu, XIN Sha-sha, DONG Yu#   

  1. School of Pharmacy, Inner Mongolia Medical University, Inner Mongolia 010059
  • Received:2014-10-12 Online:2015-03-28 Published:2015-03-28

Abstract: Objective To study the therapeutic effect of effective part of Sendeng- 4, a Mongolian medicine compound, on rat model with adjuvant arthritis (AA). Methods SD rats were randomly divided into five groups: effective part of Sendeng- 4 group (Sendeng- 4 group), Tripterygium wilfordii Hook F. group (TWHF group), celecoxib group, model group and normal group. Except the normal group, the other groups were made into AA model induced by injection complete Freund’s adjuvant into both rear voix pedis twice and were orally administrated corresponding drugs for 20 consecutive days after the second immunization. The rat paw swelling degree were calculated by measurement of the volume of rat paw. The concentration of serum tumor necrosis factor-α (TNF-α), prostaglandin-2 (PGE2) and interleukin-6 (IL-6) were detected by using ELISA kit. Results Compared with model group, the rat paw swelling degree decreased significantly in Sendeng- 4 group, TWHF group and celecoxib group(P<0.05), while, those of the three treatment groups had no difference compared with normal group. Compared with model group, the concentration of TNF-α, PGE2 and IL-6 decreased significantly in three treatment groups(P<0.05) . Conclusion Mongolian medicine Sendeng- 4 inhibites TNF-α, PGE2 and IL-6 in serum which are regarded as rheumatoid arthritis inflammatory cytokines, leading to effective treatment of the patients of rheumtoid arthritis.

Key words: Mongolian medicine Sendeng- 4, rat paw swelling degree, adjuvant arthritis, tumor necrosis factor-α , prostaglandin-2, interleukin-6

CLC Number: 

  • R285.5