主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (4): 253-259.doi: 10.3969/j.issn.1006-2157.2015.04.008

• Orignal Article • Previous Articles     Next Articles

Preparation and in vitro evaluation of analgesic microemulsion cataplasm*

ZHANG Ye-wen, WANG Qiong, YU Jing-xin, LI Hui, KANG Qian, ZHANG Qing, TAN Peng, WU Qing#   

  1. School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102
  • Received:2014-10-15 Online:2015-04-15 Published:2015-04-15

Abstract: Objective To investigate the influence of microemulsion technology on release capability and transdermal permeability of components in cataplasm. Methods With the initial bonding strength, 180 degree force strength and sensory evaluation scores as indicators, the formula of the analgesic microemulsion cataplasm matrix was optimized by using single factor experiment combined with central composite design-response surface design methodology. Modified Franz diffusion cell was used to compare the release capability and transdermal permeability between analgesic microemulsion cataplasm (MEC) and analgesic common cataplasm (CC) with indicators of ferulic acid and imperatorin. Results Optimized matrix formula was NP700, carbomer 941, carbomer 934, aluminum compounds, tartaric acid and glycerin with the ratio of 1∶0.1∶0.25∶0.04∶0.04∶6 . The release capability in vitro of ferulic acid and imperatorin in MEC and CC conformed to zero-order kinetic equation with a dual mechanism of diffusion and dissolution. The steady-state permeation rate of ferulic acid in MEC was 1.92 μg/(h·cm2) and that in CC was 0.97 μg/(h·cm2); that of imperatorin in MEC was 0.28 μg/(h·cm2), while in CC was 0.09 μg/(h·cm2). Compared with CC, the cumulative release rate of effective components multiplied. Conclusion Microemulsion technology can significantly promote the transdermal permeability of components in cataplasm.

Key words: microemulsion, cataplasm, central composite design-response surface design methodology, ferulic acid, imperatorin, release capability in vitro, transdermal permeability

CLC Number: 

  • R283.62+1