主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (4): 260-265.doi: 10.3969/j.issn.1006-2157.2015.04.009

• Orignal Article • Previous Articles     Next Articles

Distribution of common syndrome elements of disease nature in 801 patients with viral hepatitis cirrhosis: a comparison between compensation stage and discompensation stage*

ZHAO Li-hong1,WANG Tian-fang1#, XUE Xiao-lin1,WU Xiu-yan1,LI Ning1,LI Yong-gang2,LI Xin3,CHEN Sheng-duo4, SUN Feng-xia5,LI Xiu-hui6,MAO De-wen7,LIU Yan-ling8,ZHANG-Chang9,LIU Wen10, ZHANG Qiu-yun11   

  1. 1 Beijing University of Chinese Medicine,Beijing 100029;
    2 Chinese PLA 302 Hospital;
    3 Dongzhimen Hospital;
    4 Chinese Medicine Hospital of Hubei Province;
    5 Beijing Ditan Hospital;
    6 Beijing You’an Hospital;
    7 First Affiliated Hospital of Guangxi College of Chinese Medicine;
    8 Xiyuan Hospital;
    9 Dongfang Hospital;
    10 Beijing Hospital of TCM;
    11 School of Traditional Chinese Medicine,Capital University of Medical Sciences
  • Received:2014-11-02 Online:2015-04-15 Published:2015-04-15

Abstract: Objective To discover the rules of distribution and combination of common syndrome elements in vital hepatitis cirrhosis(VHC) patients based on the method of combination of syndrome and diseases, so as to guide the TCM clinical practice.Methods A national multicenter and cross-section epidemiological survey was conducted by using Information Collection form of Vital Hepatitis Cirrhosis drafted by the research group to collect the TCM symptoms, tongue manifestation and pulse condition.Based on consensuses on clinical diagnosis and treatment of VHCliterature review, Standard of Hepatitis Cirrhosis Syndrome Elements Differentiation was established after two-round experts approval, on which the syndrome elements of 801 patients were determined.Descriptive statistics and Chi-square test were applied. Results Altogether 7 syndrome elements of disease nature lied in 801 patients with viral hepatitis cirrhosis:517 cases of qi deficiency, 503 cases of blood stasis, 462 cases of water retention, 448 case of yin deficiency, 438 cases of qi stagnation, 428 cases of yang deficiency and 257 cases of damp heat, in addition, the frequency of qi deficiency, blood stasis, damp heat and yang deficiency was higher at discompensation stage than that of the compensation stage (P<0.05). In 314 patients of compensation stage, the frequency of blood stasis (36.36%), qi deficiency & qi stagnation(20.00%), qi deficiency & yin deficiency & blood stasis(11.32%), qi deficiency & yang deficiency & yin deficiency & qi stagnation(16.13%) and qi deficiency & yang deficiency & yin deficiency & qi stagnation & blood stasis(45.1%) was the highest in distribution of single and combination of syndrome elements, respectively.In 487 patients of discompensation stage, the frequency of water retention (90.91%), qi deficiency & water retention(57.45%), qi deficiency & blood stasis & water retention(26.44%), qi deficiency & yang deficiency & blood stasis & water retention(23.40%) and qi deficiency & yang deficiency & qi stagnation & blood stasis & water retention(25.00%) was the highest, respectively.With regard to combination of six types of syndrome elements, water retention was not included in 60.00% patients at compensation stage, and damp heat was not included in 59.61% patients at discompensation stage. Conclusion Single type of element and combinations of two, three, four or five types of syndrome elements were more in patients of compensation, by contrast, combination of three, four, five, six or seven types of elements were more in patients of discompensation.Qi deficiency and blood stasis were the basic pathogenesis in patients of compensation and discompensation stage, and pathogenesis features showed differently at different stages.

Key words: viral hepatitis cirrhosis, syndrome elements of disease nature, distribution

CLC Number: 

  • :R214.4