主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (6): 420-425.doi: 10.3969/j.issn.1006-2157.2015.06.012

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Dahuang Zhechong Wan for chronic hepatitis B: a systematic review*

DENG Yan-fang, QU Le, SONG Ya-nan, JIANG Yan#   

  1. School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029
  • Received:2014-12-25 Online:2015-06-15 Published:2015-06-15

Abstract: Objective To evaluate the effectiveness of Dahuang Zhechong Wan (Rhubarb and Eupolyphaga Pill) for Chronic Hepatitis B. Methods Randomized controlled trials (RCTs) of Dahuang Zhechong Wan for Chronic Hepatitis B published in domestic or foreign magazines were searched. Revman5.2 was used to perform the Meta-analysis on the curative effect of Dahuang Zhechong Wan for chronic hepatitis B. Results A total of 21 RCTs were included, among which none used Dahuang Zhechong Wan only.21 studies all used combined treatment on 1731 cases with 875 in treatment groups and 856 in control groups. The results of meta-analyses showed that at the end of the treatment, groups adding Dahuang Zhechong Wan was superior to those without. There were significant difference in both the clinical efficiency, HBV-DNA negative conversion, HBeAg negative conversion, ALT and TBil recovery. Conclusion Combined therapy using Dahuang Zhechong Wan is superior to conventional medicine alone for chronic hepatitis B. However, because of low quality of the included studies, high-quality and large-scale RCTs are needed to provide further evidence.

Key words: Dahuang Zhechong Wan, chronic hepatitis B, randomized controlled trial, systematic review

CLC Number: 

  • R256.4