主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (6): 426-429.doi: 10.3969/j.issn.1006-2157.2015.06.013

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Effects of acupuncture with different stimuli intensity on uterine contraction and expression of endocrine-related molecular receptor genes in rats with dysmenorrhea of cold coagulation pattern*

HSU Wing-sze1, ZHAO Guo-zhen2, JI Bo2#, QI Dan-dan1, GUO Meng-wei1, REN Xiao-xuan1, ZHAO Ya-fang1, ZHANG Lu-fen1, LI Xiao-hong1, ZHU Jiang1, ZHANG He1, SONG Yan1, LIU Ya-li1, ZHANG Ping1   

  1. 1 School of Acupuacture, Moxibustion and TuinaBeijing University of Chinese Medicine, Beijing 100029;
    2 Capital University of Medical Sciences
  • Received:2014-11-20 Online:2015-06-15 Published:2015-06-15

Abstract: Objective To evaluate the effects of acupuncture with different stimulation intensity at Sanyinjiao (SP6) on uterine contraction and expression of endocrine-related molecular receptor gene in rats with dysmenorrhea of cold coagulation pattern and to explore whether there is association between “deqi (qi arrival)” and stimulus intensity. Methods Diestrus female rats were randomly divided into 4 groups, including saline control group, model control group, deqi group (with strong stimulus) and No deqi group (with weak stimulus). The levels of uterine contraction was recorded during 20 mins acupuncture treatment. The expression of PGF2α mRNA was measured. Results Compared with the model control group, the uterine contraction wave number and uterine activity were significantly reduced in deqi group. The expressions of PGF mRNA in both deqi and No deqi group were also reduced compared with model group. Conclusion Our finding indicates that using thick needles, deep insertion with hand-manipulation seems more effective and could achieve desired level of “deqi” in dysmenorrhea rats.

Key words: dysmenorrhea, uterine contraction, different acupuncture stimuli, deqi, PGEP22, PGE, rats

CLC Number: 

  • R245.3