主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (7): 496-500.doi: 10.3969/j.issn.1006-2157.2015.07.014

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Laws of TCM syndromes of non-alcoholic fatty liver disease and characteristics of Chinese medicinal herbs used: a data mining based on literature

HAN Li1, WANG Guan-long2, YANG Qin-he2#, YU Yao2, ZHANG Yu-pei2, GONG Xiang-wen2, LI Yuan-yuan2   

  1. 1 The First Affiliated Hospital of Jinan University, Guangdong 510630;
    2 Medical College of Jinan University
  • Received:2015-02-05 Online:2015-07-30 Published:2015-07-30

Abstract: Objective To reveal the rules of TCM syndromes and prescription of non-alcoholic fatty liver disease(NAFLD) by using data mining methods. Methods After retrieving clinical trials of CNKI, VIP and Wanfang database related to TCM treatment and syndromes of NAFLD, besides manual searching from 2000 to 2013, the database was established. Then the literature was screened and extracted for analysis of frequency and relevance principles. Results Altogether 44 TCM syndrome patterns were involved in 124 citations included. By disintegration of the 44 syndromes, 16 syndrome factors appeared including 6 factors of disease location and 10 factors of disease nature. There were 168 Chinese medicinal herbs with the total frequency of 1 687 used in 156 prescriptions. By using relevance principle analysis, the common compatibility of crude herbs used on treatment of NAFLD was listed. Conclusion The key factors of NAFLD were phlegm, dampness, blood stasis and qi stagnation, and the disease locations were at liver and spleen. Pathogenesis were mainly syndrome of excess and syndrome of intermingled deficiency and excess. So the foundamental principle of treatment of NAFLD was reinforcement combined with elimination.

Key words: non-alcoholic fatty liver disease, data mining, syndrome, formulas and drugs

CLC Number: 

  • R575.5