主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (8): 529-531.doi: 10.3969/j.issn.1006-2157.2015.08.005

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The mRNA expressions of ILL-22, IL-22R1, STAT3 and c-myc in skin lesions of patients with psoriasis vulgaris and their correlations*

CHEN Xi, LI Ling-ling, ZHANG Run-tian, XIA Meng, DONG Bin, DUAN Xing-wu#   

  1. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700
  • Received:2015-02-28 Online:2015-08-30 Published:2015-08-30

Abstract: Objective To investigate the roles of IL-22, IL-22R1, Stat3 and c-myc mRNA expressions in abnormal proliferation of keratinocytes in psoriasis vulgaris. Methods Biopsies of skin lesions were conducted in 23 patients with psoriasis vulgaris and the skin samples of 11 normal control subjects. Levels of IL-22,IL-22R1, Stat3 and c-myc mRNA expressions were measured with reverse transcription-polymerase chain reaction (RT-PCR). Results IL-22, IL-22R1, Stat3 and c-myc mRNA were positively expressed in the psoriatic skin lesions as well as the normal controls. But the levels in the psoriatic skin lesions were significantly higher than those in the normal controls (P<0.01). There were positive correlations between the expression of IL-22 mRNA and that of IL-22R1/Stat3 mRNA (P<0.05). There were also positive correlations between the expression of Stat3 mRNA and that of c-myc mRNA (P<0.05). Conclusion The activation of Stat3 induced by IL-22 may lead to excessive proliferation of keratinocytes in psoriasis vulgaris, which could provide a new perspective in the treatment.

Key words: psoriasis vulgaris, Interleukin-22, IL-22R1, Stat3, c-myc

CLC Number: 

  • R275.9