主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (8): 539-545.doi: 10.3969/j.issn.1006-2157.2015.08.008

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Quality representation and correlation analysis of medicinal
preparation of Kaixin San based on drug system*

LI Huan-juan1, ZHANG Lu1, QUAN Jian-ye1, YANG Shu-juan1, YANG Yuan1, CHEN Wei1, SUN Dao-han1, FENG Duo1, JIANG Yan-yan1, SHI Ren-bing1,2#   

  1. 1 Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese Medicine, School of Materia Medica, Beijing University of Chinese Medicine, Beijing 100102;
    2 Quality Control Technology and Engineering Center of Chinese Medicine, Beijing Municipal Commission of Education
  • Received:2014-12-30 Online:2015-08-30 Published:2015-08-30

Abstract: Objective To determine the key factors affecting the quality of Kaixin San Heart-opening powder and the best preparation forms of Kaixin San,laying the groundwork of anti-dementia drug development from Kaixin San. Methods The content of effective index components of medicinal-preparation of Kaixin San was detected by using HPLC. The quality of medicinal preparation from Kaixin San were characterized based on the content,relative quantity,relative ratio of content, yield rate and anti-dementia effect,and the characterized Results were given correlation analysis. Results The method of the determination of effective index components from Kaixin San is easy to handle,accurate and highly reproducible. The effect of anti-dementia of three medicinal preparations from Kaixin San was listed in the following descending order of enrichment, ethanol extract, and water extract. The content of effective index components is higher with unique proportion, lower extraction rate,lower dosage and higher antibacterial effect,which is the best form in medicinal-preparation application of Kaixin San. Conclusion The key to the improvment of efficacy is to explore the fittest content and relative ratio of medicinal components based on the basic composition of Kaixin San and yield rate.

Key words: drug system, medicinal-preparation of Kaixin San, quality characteristics, correlation analysis

CLC Number: 

  • R284.1