主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (10): 690-693.doi: 10.3969/j.issn.1006-2157.2015.10.010

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Antioxidant effects of Gehua JieCheng Fang on orthotopic allograft HCC mice*

WANG Jinghui1, TANG Dongxin1, HUANG Hui1, LUO Li1, LONG Fengxi2, LI Jun2, WANG Dingxue1, YANG Zhu2#   

  1. 1.First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guizhou 550001;
    2.Guiyang College of Traditional Chinese Medicine
  • Received:2015-03-22 Online:2015-10-30 Published:2015-10-30

Abstract: Objective To observe the antioxidant effects of Gehua JieCheng Fang (Kudzuvine Flower Formula for hang-over symptoms) on the orthotopic allograft mice. Methods Orthotopic allograft models were established using H22 ascites tumor cells. Cancerous mice were then treated. Pathological changes of the hepatic lobe were microscopically observed after HE staining. Levels of superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), and Malondialdehyde (MDA) in the serum were determined by using ELISA methods. Expression levels of SOD, GSH-Px, and MDA in hepatic tissues were compared. Results Liver of the orthotopic allograft mice induced by H22 ascites tumor cells presented with pathological changes of unlimited proliferation and necrosis. Gehua JieCheng Fang affected the expression of SOD, MDA, and GSH-Px, which demonstrated the antioxidant effects. It could slow down carcinogenesis in these mice. Conclusion Gehua JieCheng Fang seems to have therapeutic effects on mice with hepatocarcinoma induced by H22 ascites cells. Its mechanism is related to the activation of antioxidation.

Key words: Gehua JieCheng Fang, hepatocarcinoma, orthotopic allograft, antioxidation, mouse

CLC Number: 

  • R285.5