主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (10): 703-708.doi: 10.3969/j.issn.1006-2157.2015.10.013

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Correlation analysis between pharmacokinetics of Kaixin San, Radix Polygalae and its monomer based on internal representations of sibiricose A5 and A6 in rats with acquired dysmnesia*

BA Yinying1, JIANG Yanyan2,3, WU xia1, SHI Renbing2,3#   

  1. 1.School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069;
    2.School of Traditional Chinese Pharmacy, Beijing University of Chinese Medicine, Key Unit of Exploring Effective Substances of Classical and Famous Prescription of SATCM;
    3.Quality Control Technology and Engineering Center of Chinese medicine, Beijing Municipal Commission of Education
  • Received:2015-04-25 Online:2015-10-30 Published:2015-10-30

Abstract: Objective To study anti-dementia effects of Kaixin San (Joyful Powder) and Radix Polygalae's based on pharmacokinetic characteristics of sibiricose A5, sibiricose A6, 3,6'-disinapoyl sucrose, and polygala xanthone III in rats with acquired dysmnesia model from three levels: monomer, medicinal and formula. Method Serum concentrations of sibiricose A5 and sibiricose A6 after oral administration in rat model were measured by using HPLC-PDA Pharmacokinetic data were obtained. Then different forms of sibiricose A5 and A6 were compared with correlation analysis (PK-DI) . Result Concentration-time curves showed that the pharmacokinetic profiles were similar in the absorption phase when Radix Polygalae extract and Kaixin San were orally administered. A bimodal pattern of sibiricose A5 and A6 in the serum profile was revealed. However, this phenomenon was not observed in the group of monomer. Radix Polygalae extracts and Kaixin San were similar in the measurements of AUC, and levels of monomer were decreased significantly (P< 0.01). Compared to the oral administration of Radix Polygalae extract, Cmax-1 and Cmax-2 of Kaixin San were increased significantly (P< 0.05).Conclution The results showed that the absorption of sibiricose A5 and A6 in rats was superior when Kaixin San was administered. This finding supports the rationale for using the Kaixin San combination in clinical use.

Key words: Kaixin San, Polygala tenuifolia wild., sibiricose A5, sibiricose A6, pharmacokinetic, drug properties

CLC Number: 

  • R284.1