主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (11): 749-752.doi: 10.3969/j.issn.1006-2157.2015.11.007

• Original Article • Previous Articles     Next Articles

Effects of TCM therapy method of yang-warming and fluid retention-resolving on expression of aquaporin-2 in kidney of rats with congestive heart failure*

XU Jianhu1,2,ZHANG Qi1#,YANG Ziqing1,LUO Chiqiong1,LI Leibing1,REN Xiaotong1,LI Linxian1, XU Lu1, XIAO Hua1   

  1. 1 Chengdu University of Chinese Medicine TCM, Sichuan 610075;
    2 School of Chinese Medicine, Ningxia Medical University
  • Received:2015-02-16 Online:2015-11-30 Published:2015-11-30

Abstract: Objective To explore the potential mechanism of eliminating fluid-retention by yang-warming and fluid retention-resolving method. Methods Rat model of congestive heart failure (CHF) was established by intraperitoneal injection of adriamycin. After modeling, the CHF rats were randomly divided into model group, group of yang-warming and fluid retention-resolving formula (YWFRR group), and group of yang-warming and fluid retention-resolving formula minus cinnamon twig (YWFRR-CT group). The rats of YWFRR group were intragastrically administered (i.g.)YWFRR at the dose of 12 g/kg once daily for consecutive four weeks, and those of YWFRR-CT were i.g. YWFRR-CT at the dose of 10 g/kg once daily for four weeks, at the same time, the rats of model group and blank group took no medication treatment. Then the serum level of brain natriuretic peptide (BNP) and protein expression of aquaporin-2 (AQP2) in renal tissue were determined. Results Compared with the blank group , the serum content of BNP in model group increased significantly and the expression of AQP2 in renal tissue decreased significantly (P<0.05 or P<0.01). The contents of serum BNP were both lower in YWFRR group and YWFRR-CT group than that of model group, and the expression of AQP2 higher. Conclusion The method of yang-warming and fluid retention-resolving could decrease the serum content of BNP and upregulate the expression of renal AQP2 of CHF rats.

Key words: yang-warming and fluid retention-resolving, congestive heart failure, aquaporin-2, brain natriuretic peptide, rats

CLC Number: 

  • R285.5