主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (11): 756-761.doi: 10.3969/j.issn.1006-2157.2015.11.009

• Original Article • Previous Articles     Next Articles

Distribution of TCM syndrome elements at active stage and at stationary stage and their correlation with serum homocysteine level: a study of 715 patients with hepatitis cirrhosis*

HOU Shuaiying1, WANG Tianfang1#, XUE Xiaolin1, WU Xiuyan1, ZHAO Lihong1, LI Yonggang2, LI Xin3, LI Ning1, REN Hong1,LIU Lulu1,ZHANG Xiaona1, LUO Qingxiang1,ZHANG Jiayuan1   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029;
    2 Chinese PLA 302 hospital;
    3 Dongzhimen Hospital ,Beijing University of Chinese Medicine
  • Received:2015-04-15 Online:2015-11-30 Published:2015-11-30

Abstract: Objective To explore the characteristics of distribution of TCM syndrome elements of disease nature between active stage and stationary stage of patients with hepatitis cirrhosis, and to study the correlation between the TCM syndrome elements and serum level of homocysteine (Hcy). Methods By using Information Collection Form of Hepatitis Cirrhosis drafted by our research team, a national multicenter and cross-sectional epidemiological survey was conducted to collect the general condition, symptoms, and blood samples from which the serum Hcy levels were obtained. In accordance with Standard of Hepatitis Cirrhosis Syndrome Elements Differentiation, the TCM syndrome elements of nature of the patients were determined. Then the correlation of the TCM syndrome elements and the serum levels of Hcy was investigated at active stage and stationary stage. Results Altogether 715 patients were included. The frequency of all syndrome elements in patients of active stage were higher than those in patients of stationary phase, in which the element of blood stasis, yin deficiency, qi deficiency, yang deficiency and water retention showed statistical differences (P<0.05). The serum level of Hcy in patients of active stage was higher significantly than that of stationary stage (P<0.05). The Hcy level of patients with yin deficiency pattern was lower than that of patients without yin deficiency pattern, the same as element of damp heat, qi stagnation and yang deficiency; however, the situations of element of blood stasis, qi deficiency and water retention were quite the reverse. In the patients of stationary stage, the serum levels of Hcy showed significant difference between qi stagnation group and non qi stagnation group (P<0.05). In the patients of active stage, the levels of Hcy showed difference between yin deficiency group and non yin deficiency group, as well as the element of qi deficiency (P<0.05). Conclusion The frequency of TCM syndrome elements and the serum Hcy level in patients of active stage higher than those of patients of stationary stage, reflected the degree of hepatic inflammation and severity of disease. That the correlation between the Hcy level and the TCM syndrome elements of nature could provide the evidence for pathological basis and standardization study of TCM syndrome elements in patients with hepatitis cirrhosis.

Key words: liver cirrhosis, syndrome elements, homocysteine, active stage, stationary stage

CLC Number: 

  • R256.4