主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (11): 767-771.doi: 10.3969/j.issn.1006-2157.2015.11.011

• Original Article • Previous Articles     Next Articles

Effect of Chinese medicine compound of cooling blood and detoxification on Th1/Th2 balance of psoriasis vulgaris patients with TCM syndrome of blood heat*

SUN Shaoxin1,XU Jie2,ZHOU Yuefei2,DONG Bin3,JIN Qinshuo3,QU Xing3,DUAN Xingwu3,LI Lingling3#   

  1. 1 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100070;
    2 Beijing University of Chinese Medicine;
    3 Dongzhimen Hospital, Beijing University of Chinese Medicine
  • Received:2015-05-16 Online:2015-11-30 Published:2015-11-30

Abstract: Objective To investigate Xiaoyin Jiedu formula (XYJDF), a Chinese medicine compound formulated by TCM method of cooling blood and detoxification, on peripheral T cell subset and the balance of type 1 helper T cells (Th1) and type 2 helper T cells (Th2) of psoriasis vulgaris (PV)patients with syndrome of blood heat, and to try to explore the potential immunological mechanism of XYJDF on treatment of PV at progression stage and stationary stage. Methods 80 patients (progression stage and stationary stage) were randomly divided into treatment group and control group, each 40 cases. The patients of the treatment group took orally XYJDF and those of the control group took orally XiaoYin capsule for consecutive eight weeks. Psoriasis Area and Severity Index score (PASI) and peripheral CD3+, CD4+, CD8+, and the balances of CD4+ / CD8 + and Th1 / Th2 were recorded before and after treatment. Results After eight-week-treatment, PASI scores decreased and the contents of CD4+ increased both in two groups(P<0.05), but only in the treatment group the content of CD8+and Thl decreased(P<0.05). Conclusion XYJDF could effectively reduce PASI score of the psoriasis vulgaris patients with syndrome of blood heat by the way of regulating patient blood contents CD3+, CD4+ and CD8+, as well as the balance of CD4+ / CD8+ and Th1 / Th2.

Key words: psoriasis vulgaris, syndrome of blood heat, Xiaoyin Jiedu formula, peripheral T cell subset, balance of Th1/Th2, immunological mechanism

CLC Number: 

  • R275.1