主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (11): 772-776.doi: 10.3969/j.issn.1006-2157.2015.11.012

• Original Article • Previous Articles     Next Articles

Effects of method of nourishing heart and spleen on estrogen, progestin and TCM syndrome score in patients with postpartum depression*

WANG Dan, ZHAO Ruizhen, LI Xiaoli, XU Fang, TANG Qisheng#   

  1. Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029
  • Received:2015-03-16 Online:2015-11-30 Published:2015-11-30

Abstract: Objective To evaluate the efficacy and safety of Shenqi Jieyu formula (SQJYF), a Chinese medicine compound formulated by the method of nourishing heart and spleen, on patients with postpartum depression (PD), so as to provide more evidence for Chinese medication treatment no depression. Methods Altogether 60 PD patients with the syndrome of deficiency of both heart and spleen from the third affiliated hospital and three communities were included, who were randomly divided into treatment group and placebo group (n=30 each). The patients of the treatment group were taken orally SQJYF one dose daily, while patients of the placebo group were taken starch particles at the same dose for consecutive six weeks. The efficacy was assessed by using TCM Depression Scale as well as measuring serum estrogen, progestin before treatment, at the first week, second week, fourth week and sixth week of treatment. Results The total effective rate of treatment group was 86.67%, while 73.33% of the placebo group; the clinical control rate of treatment group was 26.67% to 10.00% in the placebo group. There was significant difference in decreasing rate of TCM score between the two groups at the second week, fourth week and sixth week after treatment (P<0.05). The serum levels of estrogen both increased in two groups. There were significant difference between before and after treatment of each group, and the serum estrogen in treatment group was higher than that in placebo group(P<0.05). The serum levels of progestin both decreased in two groups. After six-week-treatment, the levels showed significant difference between before and after treat(P<0.05), while no difference was proved between the two groups(P> 0.05). Conclusion SQJYF had the advantages of rapid onset and less side effects by decreasing TCM syndrome scores and the serum level of estrogen, and increasing the serum level of progestin, on PD depression patients with the syndrome of deficiency of both heart and spleen.

Key words: postpartum depression, heart and spleen deficiency syndrome, sex hormones, Shenqi Jieyu formula, TCM Depression Scale

CLC Number: 

  • R271.43