主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2015, Vol. 38 ›› Issue (11): 789-792.doi: 10.3969/j.issn.1006-2157.2015.11.016

• Original Article • Previous Articles    

Electro-acupuncturing at “Baihui” point and “Zusanli” point on beha- vior and mRNA expression of intestinal NK1 receptor in rats with irritable bowel syndrome*

ZHAO Yafang1,GUO Mengwei1,WANG Shun1,YANG Shuai2,FENG Xiaoxiao1,REN Xiaoxuan1#   

  1. 1 School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine, Beijing 100029;
    2 Massage Division,Beijing Changping Hospital of TCM
  • Received:2015-06-17 Online:2015-11-30 Published:2015-11-30

Abstract: Objective To observe the effects of electro-acupuncturing (EA) at “Baihui”(DU20)and “Zusanli” (ST36) on the visceral sensitivity and emotional and psychological behavior of the irritable bowel syndrome (IBS) model rats, and to explore the double adjustment of electro-acupuncture on chronic visceral pain with emotional and psychological dysfunction. Methods Wistar immature rats were randomly divided into normal group, model group and electro-acupuncture group. The IBS model was induced by mechanical colorectal irritation of acetic acid combined with maternal separation in the postnatal period. Rats of normal group and model group underwent no intervention while those of electro-acupuncture group were needled at “Baihui” and “Zusanli” every other day for ten days. The visceral sensitivity was evaluated and the open-filed test was used, and the mRNA of neurokinin-1(NK1) receptor was detected by using RT-PCR. Results The treatment of acupuncture reduced significanty the visceral sensitivity, crossing activity and vertical activity in open field test, and the mRNA expression of NK1. Conclusion The double adjustment of electro-acupuncturing at “Baihui” and “Zusanli” on chornic visceral sensitivity with emotional and psychological dysfunction was proved.

Key words: irritable bowel syndrome, electro-acupuncture, visceral sensitivity, emotion, neurokinin-1 receptor, rats

CLC Number: 

  • R245.3