主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (1): 77-81.doi: 10.3969/j.issn.1006-2157.2016.01.015

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Effects of spleen-fortifying and kidney-replenishing therapy on manifestation and quality of life in patients with systemic lupus erythematosus disease*

YANG Xiaojing1, HUANG Chuanbing2#, LIU Yifei1, YANG Xiuli1, JIA Jingyun1, WU Min1   

  1. 1 Anhui University of Chinese Medicine, Anhui 230038;
    2 The First Affiliated Hospital of Anhui University of Chinese Medicine
  • Received:2015-04-08 Online:2016-01-30 Published:2016-01-30

Abstract: Objective To explore the effects of spleen-fortifying and kidney-replenishing therapy on manifestation and quality of life in patients with systemic lupus erythematosus disease (SLE). Methods 50 SLE patients were randomly divided into treatment group and control group. Both groups were given prednisone tablets combined with hydroxychloroquine sulfate while the treatment group also took the Spleen-fortifying and Kidney-replenishing Decoction (Jianpi Yishen Tang). Changes of clinical manifestations and laboratory parameters before and after treatment were used to evaluate the efficacy and effects on the quality of life. Results Total effective rate of 88.0% with 4 cases of clinical response, 10 cases of remarkable effect, 8 cases of effect and 3 cases of non-respond in the treatment group, was significantly higher than 72.0% of the control group (clinical response 2 cases, remarkable effect 6 cases, effect 10 cases and non-response 7 cases) (P<0.05). There was no significant difference between the two groups in SLEDAI scores. The treatment group was significantly superior to the control group (P<0.01) in improving patients’ quality of life and scores of SDS and SAS. TCM symptom scores in the treatment group were significantly lower than those in the control group (P<0.05). IgG, CRP and other laboratory parameters in the treatment group were also significantly lower than that of the control group (P<0.05). Levels of IgM, C4, WBC, and RBC in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Spleen-fortifying and kidney-replenishing therapy could significantly attenuate clinical manifestations, disease activity, TCM symptom scores and relieve anxiety and depression in SLE patients. The efficiency and safety had been proved to improve the quality of patents’life.

Key words: spleen-fortifying and kidney-replenishing therapy, systemic lupus erythematosus, efficacy evaluation, quality of life

CLC Number: 

  • R259.324.+1