主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (2): 101-105.doi: 10.3969/j.issn.1006-2157.2016.02.003

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Research on plasma metabolites of chronic heart failure patients with blood stasis pattern*

WANG Juan1, ZHAO Huihui1, CHEN Jianxin1, DENG Dong1, GUO Shuzhen1, LI Zhongfeng2, LUO Liangtao3, WANG Wei1#   

  1. 1 Beijing University of Chinese Medicine, Beijing 100029;
    2 Capital Normal University;
    3 Capital Medical University
  • Received:2015-09-15 Online:2016-02-28 Published:2016-02-28

Abstract: Objective To study the changes of metabolites in chronic heart failure (CHF) patients of blood stasis pattern by applying nuclear magnetic resonance (NMR). Methods Demographic data were collected from CHF patients of blood stasis pattern using cross-section survey. Their blood samples were also obtained and then magnetic resonance spectrum with pattern recognition techniques were used for integral calculation and normalization based on chemical shift. All data were imputed into SIMCA-P software and the Results were analyzed by using orthogonal projections to latent structures-discriminant analysis (OPLS-DA) model. Results The OPLS-DA analysis of plasma samples could differentiate and predict blood stasis pattern. Increased levels of lactate, alanine, and pyruvic acid with decreased levels of histidine, glycine, valineas, and other metabolites constitute the metabolomics profile of blood stasis pattern. Conclusion This study showed a profile of altered metabolites related to energy utilization and fatty acid metabolism in plasma samples of CHF patients with blood stasis pattern, which could offer a new approach to the diagnosis and treatment of CHF.

Key words: nuclear magnetic resonance, metabonomics, chronic heart fallure, orthogonal projections to latent structures-discriminant analysis

CLC Number: 

  • R241.4