主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (2): 132-135.doi: 10.3969/j.issn.1006-2157.2016.02.009

Previous Articles     Next Articles

Neuroprotective effects of kidney-tonifying and blood-activating medicinals on optical nerve in glaucomatous eyes after filtering surgery*

WANG Wei1,2, LI Yan 2, LIU Hongji1, ZHU Xinping 1, LI Xiang 3#   

  1. 1 Chengdu University of Traditional Chinese Medicine, Sichuan 610072;
    2 Traditional Chinese Medicine Hospital Affiliated to Sichuan Medical University;
    3 Teaching Hospital of Chengdu University of Traditional Chinese Medicine
  • Received:2015-09-21 Online:2016-02-28 Published:2016-02-28

Abstract: Objective To observe the neuroprotective effects of kidney-tonifying and blood-activating medicinals on optical nerve in glaucomatous eyes after filtering surgery with intraocular pressure(IOP) under control. Methods A prospective study was conducted to enroll 36 cases of primary glaucoma after filtering surgery with IOP under control. The subjects were randomly divided into control group and treatment group. The control group received monitoring and IOP control management only while the treatment group was added oral intake of kidney-tonifying and blood-activating medicinals for three treatment courses (each course lasts two months with a total of six months). Visual acuity, IOP, visual field, optic nerve scanning, and VEP were evaluated before and after treatment. Results The visual acuity and IOP of two group showed no significant changes before and after treatment. After treatment,mean sensitivity (MS), mean defect (MD), loss variance (LV), average retinal nerve fiber layer thickness (RNFL), and pattern visual evoked potential (LP100, AP100) were significantly improved in the treatment group (P<0.05).There was no significant change in C/D and RA in the treatment group after treatment (P>0.05). There were no significant changes in all parameters in the control group after treatment (P>0.05). Compared with the control group, MS , MD, LV, average RNFL’s thickness, LP100, and AP100 of two groups were statistically significant after treatment (P<0.05). Conclusion Kidney-tonifying and blood-activating medicinals could improve vision, VEP and RNFL thickness in primary glaucomatous eyes after filtering surgery thereby protecting the optic nerve and visual function in glaucomatous patients.

Key words: glaucoma, neuroprotection, kidney-tonifying and blood-activating medicinals, clinical research

CLC Number: 

  • R276.7