主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (2): 173-176.doi: 10.3969/j.issn.1006-2157.2016.02.017

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Effects of acupuncture along meridians on the expression of Toll-like receptor 4 protein in myocardium of myocardial ischemic rats*

CHENG Zedong, YU Songzai, CHEN Yiguo   

  1. School of Acupuncture-Moxibustion and Tuina, Liaoning University of Traditional Chinese Medicine, Liaoning 110032
  • Received:2015-08-22 Online:2016-02-28 Published:2016-02-28

Abstract: Objective To study the effects of electro acupuncture (EA) on selected acupoints along meridians on cardiac Toll-like receptor 4 (TLR4) in SD rats with myocardial ischemia induced by isoprenaline hydrochloride (ISO). Methods 50 male SD rats were randomly divided into five groups (n=10 each). ISO was subcutaneously injected in all groups except the blank group to establish the myocardial ischemia model. After successful modeling, EA was applied at corresponding acupuncture point for rats in the Neiguan (PC6) group, the Lieque (LU7) group and the non-acupoint (mid-point between RN8 and ST25) group. Myocardial tissue of the rats were obtained after the final EA. Superoxide dismutase (SOD) activities, creative kinase (CK-MB), morphology of cardiac tissue and cardiac TLR4 protein expression were evaluated. Results Compared with the model group, the rats of PC6 group myocardial fibers were arranged more and appeared more orderly with complete structure; cell interstitial infiltration of inflammatory cells was not apparent. The serum SOD contents were significantly increased, while the levels of CK-MB and TLR4 protein in myocardial tissue were significantly decreased. There were no significant differences between the above parameters in the non acupoint group and the LU7 group when compared to model group. Conclusion The mechanism of the therapeutic effect of EA at Neiguan (PC6) on myocardial ischemia is probably by regulating the expression of myocardial tissue TLR4 protein.

Key words: myocardial ischemia, electro-acupuncture, corresponding channel point selection, Neiguan (PC6), Toll-like receptor 4, rats

CLC Number: 

  • R285.5