主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (4): 325-334.doi: 10.3969/j.issn.1006-2157.2016.04.012

Previous Articles     Next Articles

Correlation between TCM constitution and metabolic syndrome: a systematic review and Meta-analysis*

LUO Hui1,2, WANG Qi1#   

  1. 1 Constitution and Reproductive Medicine Research Center , Beijing University of Chinese Medicine, Beijing 100029;
    2 Institute for Traditional Tibetan Medicine,China Tibetology Research Center
  • Received:2015-12-26 Online:2016-04-30 Published:2016-04-30

Abstract: Objective Based on the current studies of the correlation between TCM constitution and metabolic syndrome (MS), to study the distribution rule of TCM constitution of patients with MS, so as to provide proof of evidence-based medicine (EBM) for prevention and treatment of MS. Methods After searching China National Knowledge Infrastructure (CNKI), Chongqing VIP Chinese Science and Technology Periodical Database (VIP), Wanfang Data, PubMed, and Embase, all clinical literature linked to the correlation between constitution and MS were included. The meta-analysis of cross-sectional studies was conducted using R version 3.2.2 software, and the Meta-analysis of case-control studies was finished using Review Manager 5.3 software with rate or odds ratio (OR) and 95% confidence interval (CI) as effect size. Results 13 cross-sectional studies and 2 case-control studies were eligible, with 6 742 MS patients and 3 576 of control group. The constitution of phlegm-dampness, qi-deficiency and damp-heat accounted for 30% (22%~40%), 19% (13%~28%) and 14% (10%~20%) of MS patients respectively. The meta-analysis of case-control studies showed that OR of occurrance risk of MS in patients with constitution of phlegm-dampness, qi-deficiency, damp-heat were 5.87 (1.94~17.79), 1.17 (1.01~1.37) and 1.96 (1.65~2.33) respectively. Each of the three TCM constitutions mentioned above took up the highest proportion in MS patients of North China, the lowest proportion in East China, and the middle in South China. There was no gender difference on the rate of phlegm-dampness constitute, while the rate of qi-deficiency constitution in female was higher than male with damp-heat constitution reversely. The methodological quality of the two case-control studies was high, and that of the cross-sectional studies was low with higher bias risk. Conclusion The constitution of phlegm-dampness, qi-deficiency and damp-heat were the primary types in patients with MS, which were believed to be the risk factors of the incidence of MS,furthermore, the phlegm-dampness constitution was the closest with MS. We suggest that the clinical study should conduct and report in accordance with the consolidated standards to improve the study quality, so as to explore the correlation of constitutions and diseases, and to support the diagnosis and treatment model of “differentiation of constitution-pattern-disease”.

Key words: TCM constitution, metabolic syndrome, correlation, systematic review, Meta-analysis

CLC Number: 

  • R22