主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (5): 372-375.doi: 10.3969/j.issn.1006-2157.2016.05.005

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Experimental study on dermal safety of Majie Pingchuan cataplasm*

ZHU Wenxiang, LIU Yuanjun, CHENG Fafeng, LI Changxiang, WANG Qingguo, WANG Xueqian#   

  1. Beijing University of Chinese Medicine,Beijing 100029
  • Received:2015-06-23 Online:2016-05-30 Published:2016-05-30

Abstract: Objective To investigate the safety of Majie Pingchuan cataplasm on skin. Methods ①Acute toxicity test. Twelve rabbits were randomly divided into three groups with hair removed and skin damaged, systemic poisoning situation was observed after patching blank matrix cataplasm and Majie Pingchuan cataplasm. ②Skin irritation test. Sixteen rabbits were randomly divided into four groups with hair removed and skin damaged, one twelfth of one sheet of blank matrix cataplasm and Majie Pingchuan cataplasm were separately patched on left or right side skin, erythema and edema were observed in single and repeated stimulation tests. ③Skin allegy test. Thirty guinea pigs were randomly divided into three groups, one twelfth of one sheet of blank matrix cataplasm, Majie Pingchuan cataplasm, 0.2 mL of 2,4-dinitrochlorobenzene were patched on the left side skin. On 28th day allergic reaction was observed after patching the same excitants six hours continuously on the right skin. Results In the acute toxicity test, there was no death and abnormal physiological conditions in rabbits. In the single stimulus test, erythema and edema did not appear. In the repeated stimulation tset, there was slight erythema disappearing in 48 h, and no edema. In allergy test, Majie Pingchuan cataplasm group did not appear erythema and edema, the sensitization rate was 0. Conclusion Majie Pingchuan Cataplasm had no acute toxicity and irritation on intacted or injured skin of rabbits. There was no allergic reaction in guinea pig skin. Majie Pingchuan cataplasm is safe and non-toxic.

Key words: Majie Pingchuan Cataplasm, skin, acute toxicity, irritation, allergy

CLC Number: 

  • R285.5