主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (6): 520-523.doi: 10.3969/j.issn.1006-2157.2016.06.017

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Clinical observation of Bushen Qianggu Decoction on multiple myeloma*

HUANG Zhili1, YU Tianqi2, CHEN Yayong1, GUO Shanshan2   

  1. 1 Guangzhou Hospital of TCM, Guangdong 510130;
    2 Third Hospital of Guangzhou University of TCM
  • Received:2016-01-07 Online:2016-06-30 Published:2016-06-30

Abstract: Objective To observe the effects of Bushen Qianggu Decoction(BQD) on macrophage migration inhibitory factor(MIF) of patients with multiple myeloma(MM)and its clinical efficacy, so as to provide the ground for clinical promotion. Methods 30 patients who accorded with the inclusive criteria were divided into two groups randomly. BQD combined with VAD chemotherapy regimen were used in treatment group; thalidomide combined with VAD chemotherapy regimen were used in control group. The indexes of pre- and post- treatment were observed, including serum MIF, hemoglobin, serum M protein, marrow plasmacyte rate, serum calcium, serum β2 microglobulin (β2-MG) , lactic acid dehydrogenase (LDH), and C-reaction protein (CRP). And the clinical efficacy and adverse reaction were studied. Results There were statistical differences between treatment group and control group in serum MIF,hemoglobin, serum M protein, marrow plasmacyte rate, CRP (P<0.01) and β2-MG (P<0.05). There was no difference in serum calcium and LDH (P>0.05). The total effective rate in treatment group was 86.66% compared to 80% in control group, no significant differences after Ridit analysis (P>0.05). The incidence of constipation, sleepiness, edema, peripheral neuropathy of control group were significantly higher than that of treatment group (P<0.05). Conclusion The clinical efficacy of BQD on MM was close to thalidomide with obviously less adverse reactions. BQD decreased serum MIF, M protein, marrow plasmacyte rate, serum β2-MG, and CRP, increased hemoglobin, and adverse reactions were decreased significantly. This study showed that BQD has certain advantages on MM by the way of inhibiting the high expression of serum MIF and angiogenesis.

Key words: Bushen Qianggu Decoction, multiple myeloma, macrophage migration inhibitory factor

CLC Number: 

  • R273.33