主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (8): 696-700.doi: 10.3969/j.issn.1006-2157.2016.08.016

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Kongsheng Zhenzhong dispensing granule on tumor-related insomnia patients with deficiency in heart and kidney*

WANG Jun1, TIAN Shaodan2#, CHEN Xinyi2, ZHOU Yuhong1   

  1. 1 Chinese Medicine Hospital of Zhejiang Province,Zhejiang 310006;
    2 Dongzhimen Hospital , Beijing University of Chinese Medicine
  • Received:2016-03-20 Online:2016-08-31 Published:2016-08-31

Abstract: Objective To evaluate comprehensively therapeutic effect of Kongsheng Zhenzhong Pill (dispensing granule) (KSZZ), a classic TCM herbal formula, on tumor-relater insomnia patients with TCM pattern of deficiency in heart and kidney, so as to provide foundation for clinical application. Methods Sixty tumor-related insomnia patients with deficiency in heart and kidney who were conformed to the diagnostic criteria were randomly divided into control group and treatment group (each n=30). Patients in treatment group took orally KSZZ twice daily, one pack 30 minutes after breakfast and dinner, and those in treatment group took orally estazolam at dose of 1 mg at night, for consecutive 28 days. Pittsburgh sleep quality index scale (PSQI) and TCM Pattern Integral were used before treatment ,on Day 1, Day 14 and Day 28 after treatment, so as to record PSQI score, TCM clinical pattern and change of single symptom. Then the quality of sleep and TCM pattern curative efficacy were calculated by using SPSS 18.0 software. Results Compared with the control group, PSQI scores and TCM pattern integral decreased significantly (P<0.001).The curative efficacy of KSZZ on insomnia or TCM pattern was higher than that of estazolam(P<0.001). The scoring of individual symptoms on Day 14 or Day 28 were lower obviously than those on Day 1(P<0.001), except sleep efficiency on Day 14 and Day 28 (P>0.05) . Conclusion The curative effect of KSZZ on improving sleep quality of tumor-related insomnia patients has been proved, and KSZZ could be worthy of wide clinical application.

Key words: Kongsheng Zhenzhong dispensing granule, tumor-related insomnia, TCM pattern

CLC Number: 

  • R273.06