主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (9): 734-738.doi: 10.3969/j.issn.1006-2157.2016.09.007

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Correlation of TA repeat polymorphisms of estrogen receptor-α gene and TCM patterns of hypomenorrhea*

LIN Xiaohua 1,2, JIN Zhe2, LIU Jing1, TAN Zhanwang3#   

  1. LIN Xiaohua 1,2, JIN Zhe2, LIU Jing1, TAN Zhanwang3#(1 Hebei Provincial Hospital of Chinese Medicine, Hebei 050011;
    2 Dongfang Hospital, Beijing University of Chinese Medicine;
    3 Hebei Medical University
  • Received:2016-03-10 Online:2016-09-30 Published:2016-09-30

Abstract: Objective To find out the distribution of TA (thymine-adenine) repeat polymorphisms of estrogen receptor-α (ERα) gene in patients with unexplained hypomenorrhea as well as its correlation with TCM patterns of hypomenorrhea. Methods The present case-control study was carried out by using the sequencing methods to find out the TA repeat polymorphisms distribution differences in patients and controls, and in TCM patterns of patients. Results The frequency of TA19 allele in experimental group was 22.73%, significantly higher than 4.55% in control group (P=0.007) . The rank of distribution of TA19 allele in patterns listed as kidney deficiency, blood stasis and blood deficiency, showed no significant difference (X2=5.137, P=0.077). But the distribution of TA19 in pattern of kidney deficiency and blood deficiency showed significant difference(X2=4.574,P=0.032,OR=0.283). Conclusion The correlation of TA repeat polymorphisms of estrogen receptor-α gene and TCM patterns of unexplained hypomenorrhea was proved. The TA19 allele was more susceptibility to hypomenorrhea, whose association with the different TCM patterns showed no statistical significance.

Key words: hypomenorrhea, estrogen receptor-α, TA repeat sequence, TCM patterns

CLC Number: 

  • R271.11