主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (9): 744-749.doi: 10.3969/j.issn.1006-2157.2016.09.009

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Multi-target neuroprotective effect of Buyang Huanwu Decoction against cerebral ischemia injury*

LU Fang, JIANG Ludi, CHEN Yankun, LUO Ganggang, LIU Fang, LI Gongyu, ZHANG Yanling#   

  1. Beijing Key Laboratory of TCM Foundation and New Drug Research, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102
  • Received:2016-04-05 Online:2016-09-30 Published:2016-09-30

Abstract: Objective To explore the multi-target mechanism of neuroprotective effect of Buyang Huanwu Decoction (BYHWD) against cerebral ischemia injury by using molecular docking. Methods 230 ingredients and metabolites of herbal Chinese medicines of BYHWD were collected and docked with seven active binding sites of five glutamate receptors.The potential anti-cerebral ischemia injury active compounds were screened and the molecular mechanism of the active ingredients was analyzed using molecular docking. Results Calycosin, formononetin, perlolyrine and lactiflorin, main compounds of BYHWD, interacted with two or more binding sites of glutamate receptors, which showed that BYHWD’s neuroprotective effect against cerebral ischemia in the way of multiple compounds working on multiply targets and multiply sites. Majority of components from the chief drug Radix Astragali (Huangqi) and minority of components from deputy drug Radix Angelicae Sinensis (Danggui) and assistant herbs Rhizoma Chuanxiong, Radix Paepmoae Rubra (Chishao), and Flos Carthami (Honghua), consistent with the combination principles of BYHWD. Conclusion The multi-target neuroprotective effect of BYHWD against cerebral ischemia injury was studied at the molecular level, which can guide the application of BYHWD in clinic. Meanwhile, this study also can provide reference for discovering novel traditional Chinese medicines to treat cerebral ischemia injury.

Key words: Buyang Huanwu Decoction, neuroprotective, cerebral ischemia Injury, molecular docking, multi-target

CLC Number: 

  • R285.5