主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (9): 750-754.doi: 10.3969/j.issn.1006-2157.2016.09.010

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Xintong Changluo Shuli Quzhuo therapy against focal segmental glomerular sclerosis rats*

ZHAO Xi1, YANG Hongtao1#,LI Man2,LI Jie1,XU Bing3   

  1. 1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300412;
    2 Beichen Hospital of traditional Chinese Medicine, Tianjin;
    3 Tianjin University of Traditional Chinese Medicine
  • Received:2016-02-23 Online:2016-09-30 Published:2016-09-30

Abstract: Objective To study the therapeutic effect and mechanism of Xintong Changluo Shuli Quzhuo therapy (hereinafter called “TCM”) against rats with focal segmental glomerular sclerosis in rats. Methods The rat model of focal segmental glomerular sclerosis was induced by tail intravenous injection of azithromycin twice. According to their weight, all rats were divided into normal group, model group, benazepril group and TCM group (n=15 each). At the end of 9th week after modeling, the corresponding drugs were administered orally. Then at the 4th week and at the 8th week after treatment, 24 h urine protein, serum albumin, creatinine and urea nitrogen levels were measured and morphological changes were observed under light microscope and electron microscope. Results Compared with model group, each index of TCM group had significant differences, and pathological observation showed that the glomerular injury in TCM group was slighter than that in the model group. Conclusion Xintong Changluo Shuli Quzhuo therapy can obviously protect the renal function of rats, significantly reduce extracellular matrix deposition and glomerular sclerosis, delay the progress of chronic kidney disease.

Key words: glomerular sclerosis, Xintong Changluo Shuli Quzhuo therapy, rats

CLC Number: 

  • R256.5