主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (9): 774-778.doi: 10.3969/j.issn.1006-2157.2016.09.015

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Qingre Huashi Quyu therapy on chronic renal failure patients with damp-heat pattern: a multicenter randomized-controlled clinical trial*

WANG Yiping1,WANG Dong1,LI Chuanping2,LIU Shifu3,JIN Hua1,Lü Yong1,HU Shunjin1,REN Kejun1,WEI Ling1,MAO Yanping1   

  1. 1 First Affiliated Hospital of Anhui College of TCM, Anhui 230031;
    2 Lu’an City Hospital of TCM;
    3 Wuhu City Hospital of TCM
  • Received:2016-04-16 Online:2016-09-30 Published:2016-09-30

Abstract: Objective This multicenter, randomized-controlled clinical trial was designed to study the clinical efficacy of Qingshen Granule, formulated by TCM therapy principle of clearing heat (qingre), eliminating dampness (huashi) and removing blood stasis (quyu), on chronic renal failure patients with damp-heat pattern. Methods A total of 282 patients eligible were divided into treatment group (n=136) and control group (n=146). All patients were treated with conventional therapy, in addition, patients of treatment group took orally Qingshen Granule at a dose of 10 g, three times daily for consecutive 12 weeks. Results The total clinical curative effective rate of the treatment group (79.41%) was significantly higher than that of the control group(67.12%),and there were significant differences between the two groups(P<0.05). The clinical effect of TCM pattern in the treated group(86.76%) was significantly higher than that in the control group (59.59%),and there were significant differences between the two groups (P<0.01). After treatment, the levels of U-pro/24h and Scr were obviously lower (P<0.01), while eGFR was obviously higher (P<0.01), superior to the control group (P<0.05). Conclusion On the basis of conventional therapy, the satisfactory clinical efficacy of Qingshen Granule on chronic renal failure patients with damp-heat pattern was proved by ameliorating clinical symptoms, decreasing TCM pattern scores, reducing urinary protein and protecting renal function.

Key words: chronic kidney disease, damp-heat pattern, Qingre Huashi Quyu, multicenter

CLC Number: 

  • R256.5