主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (10): 875-879.doi: 10.3969/j.issn.1006-2157.2016.10.018

Previous Articles    

Effect of electro-acupuncture on Aβ in cortex and serum of APP/PS1 transgenic mice*

WANG Xin, LI Zhigang, CAO Jin, LU Menghan, Lu Wei, JING Quankai, GAO Yang, XUE Weiguo#   

  1. Beijing University of Chinese Medicine,Beijing 100029
  • Received:2016-05-11 Online:2016-10-30 Published:2016-10-30

Abstract: Objective To observe the effect of eletro-acupuncture (EA) on the expression of Aβ1-40 and Aβ1-42 in cortex and serum of APP/PS1 transgenic mice with Alzheimer’s disease (AD), so as to explore the mechanism of EA therapy on AD according to the clearance of Aβ across blood brain barrier (BBB). Methods Twenty 6-month-old APP/PS1 transgenic mice were randomly divided into model control group and EA group, and ten more C57BL/6 wild type mice were assigned into the normal control group. After one and half months’EA treatment at the acupoint“Yǒngquán”(KI 1) and“Bǎihuì”(GV 20), Aβ1-42 expression in the cortex was observed by using immunohistochemistral staining, and content of Aβ of cortex and serum were measure by ELISA method. Results In the model group, deposits of mature senile plaques were observed, which were weak in EA group . Compared with the model group, the expression of Aβ1-40 and Aβ1-42 in EA group significantly decreased (P<0.01), both in cortex and in serum. Conclusion EA therapy can decrease the content of cortex and serum Aβ, especially on Aβ1-42 which has neurotoxicity, which may be one of ways of EA treatment on AD.

Key words: Alzheimer’s disease, cortex, serum, Aβ, electro-acupuncture, mice

CLC Number: 

  • R245.9+7