主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2016, Vol. 39 ›› Issue (12): 1013-1016.doi: 10.3969/j.issn.1006-2157.2016.12.008

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Laxative-induced constipation on age-related indices: an experimental study*

FEI Wenting1, HUANG Bin2, WANG Huachao3, LIU Jianqiao4, LIU Renghai3#   

  1. 1 School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029;
    2 Beijing Rectum Hospital;
    3 Dongfang Hospital, Beijing University of Chinese Medicine;
    4 Beijing Hospital of TCM
  • Received:2016-07-11 Online:2016-12-30 Published:2016-12-30

Abstract: Objective To explore the correlation of constipation and aging, by detecting age-related indices of rat constipation model. Methods The rats were fed with Rhubarb powder, then the shape, color, weight and number of feces and the intestinal transport function within 24 h were measured to confirm the successful model. The serum SOD, thymus index and spleen index, and the expression of klotho protein in the hippocampus were compared between the healthy rats and the model rats. Results Compared with the healthy rats, the weight and number of feces of model rats within 24 h, percentages of the intestinal propulsion of activated carbon,the level of serum SOD, thymus index, and klotho protein expression in the hippocampus, as well as the optical density of the klotho target protein and klothoβctin, all declined significantly(P<0.01 or P<0.05). Conclusion Laxative-induced constipation has a certain correlation with aging, but its mechanism should be done.

Key words: laxative-induced constipation, aging, rats

CLC Number: 

  • Q285.5