主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (1): 36-40.doi: 10.3969/j.issn.1006-2157.2017.01.008

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Effect of Feixian Fang extract on angiogenesis of pulmonary interstitial fibrosis rats*

WANG Chen1, WANG Zijuan2,ZHANG Xiaomei3#, LIU Yuyue3, LIU Zhe2,QIN Huihui2, ZHANG Yuting2,GUAN Lizhen3   

  1. 1 Shunyi Hospital, Beijing Hospital of TCM, Beijing 101300;
    2 Beijing University of Chinese Medicine;
    3 Dongfang Hospital, Beijing University of Chinese Medicine
  • Received:2016-10-20 Online:2017-01-30 Published:2017-01-30

Abstract: Objective Feixian Fang is a Chinese medicine compound, formulated by the principle of invigorating lung and kidney, reducing phlegm and resolving masses, and promoting blood circulation to remove meridian obstruction. This paper aimed to investigate the effect of Feixian Fang extract (FXF) on degree of pulmonary fibrosis, change of microvessels and platelet endothelial cell adhesion molecules (CD 31, CD34) in rats with pulmonary interstitial fibrosis. Methods All rats were divided into sham operation group, model group, prednisone group, losartan group, FXF high-, mid- and low- dose group. Except the sham operation group, the rats of other six groups were instilled bleomycin of 3 mg/kg through tracheal intubation. The next day, the rats were administered intragastrically corresponding medicines for consecutive 14 d or 28 d. The degree of pulmonary fibrosis, change of microvessels were observed under electron microscope and the expression of CD31 and CD34 were detected using immuhistochemistrical methods. Results High dose and middle dose FXF inhibited the pulmonary fibrosis and pulmonary alveolar inflammation and decreased microvascular density (P<0.05). Conclusion The effect of FXF against pulmonary interstitial fibrosis can be via the way of decreasing microvascular density to induce less abnormal angiogenesis in pulmonary fibrosis.

Key words: Feixian Fang extract(FXF), pulmonary interstitial fibrosis, electron microscopy, microvascular density, platelet endothelial cell adhesion molecules 31,34 (CD31,CD34), rats

CLC Number: 

  • R285.5