主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (1): 65-69.doi: 10.3969/j.issn.1006-2157.2017.01.013

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NMR-based metabonomics study on faeces of subjects with yang-deficiency constitution*

WANG Junheng, LI Yingshuai, LUO Bin#,YUE Zijing   

  1. Beijing University of Chinese Medicine, Beijing 100029
  • Received:2016-09-12 Online:2017-01-30 Published:2017-01-30

Abstract: Objective To compare the endogenous metabolites in faece of subjects with yang-deficiency constitution and the subjects with balanced constitution (healthy persons).Methods Faece samples of 30 persons with yang-deficiency constitution and 30 healthy persons were collected and analyzed by using nuclear magnetic resonance(NMR)-based metabonomics method. And the specific metabolites of faeces of yang-deficiency constitution persons were measured using multivariate statistical analysis OSC-PLS. Results The content of butyrate,acetate,methionine,succinate,glucose in yang-deficiency constitution persons were lower than those in healthy persons, while the content of propionate, alanine, lactate were higher. Conclusion There were differences in metabolism of energy, amino acid and glucose between persons with yang-deficiency constitution and persons with balanced constitution, which should be related to the viscera function and the composition of gut microbiota.

Key words: yang-deficiency constitution, nuclear magnetic resonance (NMR), metabonomics

CLC Number: 

  • R223