主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (1): 70-76.doi: 10.3969/j.issn.1006-2157.2017.01.014

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Clinical observation of Fujian Tablet on promoting the corticospinal tract remodeling of patients with cerebral ischemic stroke*

LI Xin1,2, LIU Wei3#, QIN Ling3   

  1. 1 Shandong University of Chinese Medicine, Shandong 250014;
    2 Department of Encephalopathy, Affiliated Hospital of Shandong University of Chinese Medicine;
    3 First Clinical Medical Hospital, Shandong University of Chinese Medicine
  • Received:2015-09-06 Online:2017-01-30 Published:2017-01-30

Abstract: Objective Based on diffusion tensor imaging (DTI) technology, to noninvasively evaluate the remodeling effect of Fujian Tablet on corticospinal tract of patients with cerebral ischemic stroke (CIS) by taking activities of daily living(ADL)score and Chinese stroke scale (CSS) score as the indicators, and to assess the significance of recovery of patients’motor function. Methods 60 cases according to the inclusive criteria were randomly divided into control group and treatment group (each n=30). All patients took conventional western medicine, in addition, those in treatment group took orally Fujian Tablet for 60 days. Before and after treatment, CSS score and ADL score were recorded, and the corticospinal tract was detected by using DTI. Then the correlation between data from DTI and CSS score were analyzed. Results Improvement of patients’ activities in daily life, recovery of neurological damage in treatment group were superior to those in the control group (P<0.01). And after treatment, DTI data in the treatment group was much less than that before (P<0.01), the improvement showed significance compared with the control group (P<0.01). The positive correlation of CSS score and △FA was proved in both groups(P<0.01), with the correlation coefficient of the treatment group higher. Furthermore, no adverse effects were found in indicators of the routine blood test, liver function and kidney function. Conclusion Fujian Tablets could promote the remodeling of corticospinal tract and improve the motor function of CIS patients without increasing the risk of taking more drugs.

Key words: Fujian Tablets, cerebral ischemic stroke, diffusion tensor imaging, corticospinal tract, motor function

CLC Number: 

  • R255.2