主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (3): 237-240.doi: 10.3969/j.issn.1006-2157.2017.03.011

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Influence of Huazhuo Jiedu Fang on Akt and c-Met expressions in patients with chronic erosive gastritis (syndrome of turbidity-toxin accumulating in the interior)*

WANG Yangang1,2, TIAN Xuejiao2, LV Jingjing1, LI Diangui1   

  1. 1 Hospital of Traditional Chinese Medicine of Hebei Province Hebei 050011;
    2 Graduate School, Hebei Medical University,
  • Received:2016-08-03 Online:2017-03-30 Published:2017-03-30

Abstract: Objective To observe the clinical efficacy of Huazhuo Jiedu Fang in patients with chronic erosive gastritis (CEG, syndrome of turbidity-toxin accumulating in the interior), and investigate its effect mechanism based on the expression changes of protein kinase B (Akt) and hepatocyte growth factor receptor (c-Met) in gastric mucous tissue and serum before and after treatment. Methods The patients (n=80) were randomly divided into 2 groups according to the design of randomized single blind controlled clinical trials, and treatment group was treated with Huazhuo Jiedu Fang and control group was treated with Alatan Wuwei Wan. The expression levels of Akt and c-Met in serum and gastric mucous tissue were observed in 2 groups before and after treatment. Results The expression level of Akt decreased significantly in treatment group compared with control group (P<0.05) in serum and gastric mucous tissue, and expression level of c-Met in gastric mucous tissue decreased significantly in treatment group compared with control group (P<0.05). Conclusion Huazhuo Jiedu Fang can reduce significantly expression levels of Akt and c-Met in serum and gastric mucous tissue in patients with chronic erosive gastritis CEG (syndrome of turbidity-toxin accumulating in the interior). The effect mechanism may be that Huazhuo Jiedu Fang can regulate expression levels and activities of Akt and c-Met.

Key words: chronic erosive gastritis, syndrome of turbidity-toxin accumulating in the interior, Huazhuo Jiedu Fang, Akt, c-Met

CLC Number: 

  • R259.733