主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (3): 259-264.doi: 10.3969/j.issn.1006-2157.2017.03.015

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Central mechanism of analgesic effect of Huaisanzhen on L5 nerve root pain based on functional magnetic resonance imaging*

LIU Yijun1, YANG Yong1, ZHOU Bin1, SUN fei1, CHEN Xiaoyan1, ZHOU Youlong2#   

  1. 1 Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Henan 450008;
    2 Henan University of Traditional Chinese Medicine
  • Received:2016-05-19 Online:2017-03-30 Published:2017-03-30

Abstract: Objective To illuminate the central mechanism of analgesic effect of Huaisanzhen on nerve root pain of the fifth lumbar vertebra (L5) of lumbar disc herniation (LDH) by applying resting functional magnetic resonance imaging (fMRI). Methods The patients (n=10) with L5 nerve root pain of LDH were given the first resting fMRI, then acupuncture in acupoint of Gentong 2 of Huaisanzhen, and finally the second resting fMRI. The obtained test imagines and data were analyzed and processed by using relevant software. Results The brain regions activated by pure resting state included bilateral paracentral lobules, cingulate gyrus, thalamus and occipital lobe, third periventricular zones, optic chiasm, midbrain periaqueductal gray and cerebellar vermis and other parts. The brain regions activated by acupuncture included bilateral occipital lobe, temporal lobe, parietal lobe and left side of the midbrain, and some scattered activation regions in cerebellum. The brain regions activated after acupuncture included bilateral temporal lobe, left thalamus, splenium of corpus callosum, optic chiasm, right internal capsule, pons, midbrain periaqueductal gray and other parts. Conclusion L5 nerve root pain causes the changes of brain function areas, and activities and active levels of resting state default network are inhibited and reduced. After acupuncture in acupoint of Gentong 2, the signals reaches the functional regions of brain through nerve pathways and they were activated or inhibited resulting in analgesic effect.

Key words: functional magnetic resonance imaging, fifth lumbar vertebra, Huaisanzhen, pain

CLC Number: 

  • R245