主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (4): 339-343.doi: 10.3969/j.issn.1006-2157.2017.04.014

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Association between pattern changes and cognitive outcome in Alzheimer’s disease*

SHI Jing1, NI Jingnian1, WEI Mingqing1, ZHANG Xuekai1, LI Ting1, KANG Shenghua1, MA Fuyun1, LI Yumeng1, LIU Jianping2, WANG Yongyan3, TIAN Jinzhou1#   

  1. 1 3rd Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700;
    2 Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine;
    3 Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
  • Received:2017-01-16 Online:2017-04-30 Published:2017-04-30

Abstract: Objective To explore the association between pattern changes and cognitive outcome in patients with Alzheimer’s disease (AD).Methods The study consisted of two parts: a cross-sectional survey and a follow-up. Adults with memory complaints aged 40 to 85 years were recruited. Participants were grouped into normal cognition (NC), mild cognitive impairment(MCI)and dementia. AD Patients were followed up over 24 weeks. The mini-mental state examination (MMSE) and Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog) were used for cognitive tests. Pattern diagnosis was made by using clinical global impression of change in syndrome(CGIC-S). Results 383 participants (100 NC, 120 MCI, 125 AD, and 38 other dementia) were recruited. 73 AD patients were followed up; 46 (63%) were retained at 24 weeks. The new scale had a Cronbach’s alpha of 0.836 and interclass correlation coefficient of 0.652 (P<0.001). 50 cases were selected for a test-retest analyses with 2 weeks’ interval, Pearson r was 0.561 (P=0.004). Kidney deficiency and marrow deficiency were the only two pattern elements changed over time;the pre-post change was related to ADAS-cog change (r=0.401, P=0.003). Conclusion Kidney deficiency subscale should be a fairish test for pattern change in AD clinical trials.

Key words: Alzheimer’s disease, pattern, cognitive function, clinical trial

CLC Number: 

  • R277.742