主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (4): 344-349.doi: 10.3969/j.issn.1006-2157.2017.04.015

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Data mining of medicinal combination from Chinese medicine formula for coronary heart disease*

ZHONG Xiaoxue1,2, HE Qingyong1#, YIN Xiangjun1,2, ZHAO Guifang1,2   

  1. 1 Guang’anmen Hospital, China Academy of Chinese Medical Sciences;
    2 Beijing University of Chinese Medicine,Beijing 100029
  • Received:2016-06-13 Online:2017-04-30 Published:2017-04-30

Abstract: Objective To explore the law of medicinal combinationin traditional Chinese medicine for coronary heart disease using data mining method in order to provide reference for research and development of new drug.Methods This study built a new database based on 263 compound Chinese medicine formulas for coronary heart disease, which were selected from the National Patent Database from September 1985 to July 2015. Association rules, complex network analysis and entropy method were applied to explore the combination law of traditional Chinese compound formula using the traditional Chinese medicine inheritance system software (V2.5). Results Among the selected 263 compound formulas, the most complex one consisted of 30 herbs; the simplest,only one herb; with an average of 6.20±6.10 herbs in one formula.Activating blood and resolving stasis was the most common therapeutic principle(87 cases, 33.08%).Radix et Rhizoma Salviae Miltiorrhizae (Danshen root, Danshen) was the most frequently used herb(143 cases,54.40%); the combination of Danshen and Rhizoma Chuanxiong (Chuanxiong Rhizome, Chuanxiong), and Danshen,Chuanxiong, and Flos Carthami(Safflower, Honghua), were the most frequent couple and triple combination respectively (62, 23.57% and 33, 12.55%); Based on the association rules, frequent medicinal combination were Semen Persicae(Peach Kernel, Taoren)→Honghua(CC=0.844); Lignum Dalbergiae Odoriferae(Rosewood,Jiangxiang)→Danshen(CC=0.84); Honghua, Radix Paeoniae Rubra (red peony root,Chishao) →Chuanxiong(CC=1);Chuanxiong, Taoren→Honghua(CC=0.952). Based on complex network analysis,the core medicinals identified were Radix et Rhizoma Notoginseng(Pseudoginseng Root, Sanqi), Danshen, Honghua, Radix Angelicae Sinensis(Chinese Angelica,Danggui), Chuanxiong, Radix Astragali(Astragalus Root,Huangqi), Radix et Rhizoma Glycyrrhizae(Licorice Root, Gancao), and Radix Ophiopogonis(Dwarf Lilyturf Tube, Maidong). The new compound extracted by entropy method involved Radix Aucklandiae(Common Aucklandia Root,Muxiang), Styrax(Storax, Suhexiang) Benzoinum (Benzoin, Anxixiang), Camphora (Camphor, Zhangnao), Herba Menthae(Field Mint,Bohe), Rhizoma Alpiniae Officinarum (Galangal,Gaoliangjiang), Radix Paeoniae Alba (Galangal White Peony Root,Baishao), Pericarpium Citri Reticulatae (Citrus,Chenpi)Endothelium Corneum Gigeriae Galli (Chicken Gizzard Lining,Jineijin), and Radix Glehniae (Straight Ladybell Root,Beishashen).Conclusion This study sheds light on the combination law of Chinese medicine for coronary heart disease, and provides reference for clinical practice.

Key words: coronary heart disease, patent, association rules, complex networks, entropy method, combination rule, research and development of new drug

CLC Number: 

  • R259.44