主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (6): 463-470.doi: 10.3969/j.issn.1006-2157.2017.06.004

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Effects of Jingning Granule on attention set transfer in ADHD rats*

YAN Suyu, ZHANG Shuofeng#, ZHANG Tianrui, YANG Ailing, ZHANG Caifeng, MA Dan   

  1. School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing, 100102, China
  • Received:2017-03-02 Online:2017-06-10 Published:2017-06-10

Abstract: Objective To observe the effects of Jingning Granule on attention set shifting (AST) in rats with attention deficit hyperactivity disorder (ADHD). Methods Spontaneously hypertensive rats (SHR) were used as rat model of ADHD. Jingning granule (20.25, 10.125, 5.062 5 g/kg), Methylphenidate HCl Extended-release Tablets (Ritalin 6.75 mg/kg) and pediatric Huanglong granule (0.937 5 g/kg) were used as the intervention respectively and administered continuously for 17 days. The number of errors, burrowing times, and error rate in AST were used as the outcome measures. Results Compared with the normal control group, the number of error, error rate, and burrowing times increased in model group in Simple Discrimination (SD) phase, Compound Discrimination (CD) phase, Intra-Dimensional shift (IDS) phase, Reversal Learning (RL) phase, and Extra-Dimensional shift (EDS) phase; compared with the model group, Jingning granule reduced the frequency of error, error rate, and frequency of burrowing, and improved the attention set shifting defects in ADHD rat model. Conclusion ADHD model rats presented defected attention set shifting, and Jingning granule could effectively improve the attention set transfer ability in ADHD model rats.

Key words: Jingning granule, ADHD model, attention set transfer ability, rats

CLC Number: 

  • R285.5