主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (7): 593-598.doi: 10.3969/j.issn.1006-2157.2017.07.011

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Treatment of advanced gastric cancer with Xinjia Liangfu Granules combined with chemotherapy*

WANG Jing1, GUO Shanshan2, HOU Li1, CHEN Xinyi1, TIAN Shaodan1#   

  1. 1 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
    2 Guangzhou University of Chinese Medicine, Guangdong 510006, China
  • Received:2017-01-10 Online:2017-07-10 Published:2017-07-10
  • Supported by:
    National Natural Science Foundation of China (No. 81573959), New Teacher Special Fund for Doctoral Program of Higher Education (No. 200800261007), Science and Technology Plan of Beijing Municipal Science and Technology Commission (No. D131100002213002)

Abstract: Objective To observe the clinical efficacy of Xinjia Liangfu (Modified Galangal and Cyperus) Granules on advanced gastric cancer. Methods The patients with stage III/IV gastric cancer (n=42) were randomly divided into control group and treatment group by applying prospective randomized controlled multi-center clinical trial method. The treatment group was treated with standard chemotherapy regimens combined with Xinjia Liangfu Granules, and control group, with only chemotherapy regimens. During the therapeutic course, 2 groups were given the best supportive care and observed for 4 cycles of chemotherapy. The scores of symptoms and signs, Karnofsky performance status (KPS), pain numerical rating scale, tumor size and indexes of blood and urine routine tests, liver and renal functions and electrocardiogram were recorded on the day of grouping and at the end of each cycle of chemotherapy. Results There were 21 cases in treatment group, 20 in control group and 1 case was missed. The trial results showed that the relief of symptoms and signs was significant superior in treatment group to that in control group (P<0.005). The symptoms of stomach pain, abdominal distension and pain, fearing of cold, cold limbs and loss of appetite were relieved in treatment group (P<0.05). The improvement of total physical condition were superior in treatment group to that in control group (P<0.05). The treatment group had higher clinical remission rate compared with control group but the difference had no statistical significance (P>0.05). Xinjia Liangfu Granules had a higher safety in clinical administration. Conclusion Xinjia Liangfu Granules has the effects of relieving symptoms, improving quality of life and reducing toxic and side effects of chemotherapy, and it is safe and effective in clinic.

Key words: clinical studies, gastric cancer, Xinjia Liangfu (Modified Galangal and Cyperus) Granules, advanced gastric cancer

CLC Number: 

  • R273