主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

JOURNAL OF BEIJIGN UNIVERSITY OF TRADITIONAL CHINE ›› 2017, Vol. 40 ›› Issue (7): 603-606.doi: 10.3969/j.issn.1006-2157.2017.07.013

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Influence of Jiedu Huoxue Fang on perioperative myocardial injury in patients undergone percutaneous coronary intervention*

WANG Xindong1,2, QI Xiaoxia3#, HUANG Dan1,2, ZHANG Sujie1,2, GAO Xin1,2, ZHANG Yiyan1,2   

  1. 1 Department of Cardiovascular Diseases, Hospital of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu 210028, China;
    2 Jiangsu Academy of Traditional Chinese Medicine, Jiangsu 210028, China;
    3 Nanjing University of Chinese Medicine, Jiangsu 210023, China
  • Received:2017-02-22 Online:2017-07-10 Published:2017-07-10
  • Supported by:
    National Natural Science Foundation of China (No. 81403386), Natural Science Foundation of Jiangsu Province (No. BK20161078), Jiangsu Branch of China Academy of Chinese Medical Sciences (No. JSBY1316)

Abstract: Objective To observe the influence of Jiedu Huoxue Fang (Detoxification and Blood-Activating Granules) on perioperative myocardial injury in patients undergone percutaneous coronary intervention (PCI). Methods The patients with angina pectoris received PCI (n=160) were randomly divided into Jiedu Huoxue Fang group (n=84) and control group (n=76). The Jiedu Huoxue Fang group was given routine treatment and Jiedu Huoxue Fang (1 dose/d) 7 d before PCI. The control group was treated with basic drugs. The levels of serum creatine kinase-M B isoenzyme (CK-MB) and cardiac troponin I (cTn I) were detected before and 12 h and 24 h after PCI. Results The levels of serum cTn I and CK-MB were significantly lower in Jiedu Huoxue Fang group than those in control group 12 h after PCI (P=0.003 8, P=0.027 6) and 24 h after PCI (P=0.001 2, P=0.002 7). The constituent ratio of patients with cTn I and CK-MB increasing by 3 times more than normal value was significantly lower in Jiedu Huoxue Fang group than that in control group (P=0.008 2,P=0.007 6). Conclusion Jiedu Huoxue Fang administrated before PCI has a certain preventive effect on perioperative myocardial damage.

Key words: detoxification and blood-activating, percutaneous coronary intervention, perioperative myocardial damage

CLC Number: 

  • R259.44